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Study on the relationship between "difficulty child" and fetal behavior

Research Project

Project/Area Number 18H00994
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 09030:Childhood and nursery/pre-school education-related
Research InstitutionKyushu University

Principal Investigator

Morokuma Seiichi  九州大学, 医学研究院, 教授 (50380639)

Co-Investigator(Kenkyū-buntansha) 荒田 晶子  兵庫医科大学, 医学部, 准教授 (00266082)
大村 吉幸  東京大学, 大学院情報理工学系研究科, 特任研究員 (10598022)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords胎児 / 発達 / 育てにくさ / 自閉スペクトラム症 / 胎児行動 / 育児
Outline of Final Research Achievements

We observed the behavior of human fetuses using ultrasonography, and clarified the relationship between eye movement density, which indicates REM sleep activity, and postnatal development and sleep-wake rhythms. We also used information from the JECS study to analyze the association between maternal physical activity and sleep before and during pregnancy and children diagnosed with autism spectrum disorder (ASD) by the age of 3 years. They found that mothers who were more physically active during pregnancy had a lower risk ratio for ASD in their 3-year-olds. In addition, sleep disturbances during pregnancy tended to increase the risk ratio
In animal studies, the behavior of rat fetuses was observed by ultrasound tomography under unanesthetized conditions. Analyses of homology and neural circuit formation in human and rat development are in progress.

Academic Significance and Societal Importance of the Research Achievements

胎児の行動観察により、生後の育てにくさの要因が胎児期にはじまっていることを初めて報告し、胎児期の環境要因として母体の生活習慣が生後の児の睡眠の問題や気質と関連があること、さらに、自閉スペクトラム症発症とも関連があることを示した。
以上のように、妊娠中に生後の育てにくさや発達障害の要因があることを示したことは、学術的に意義がある。
近年、社会問題となっている発達障害の増加に関して、今後の取組に示唆を与えるものであり、社会的意義も大きいと考える。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (10 results)

All 2022 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (2 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Association of fetal eye movement density with sleeping and developmental problems in 1.5-year-old infants2022

    • Author(s)
      Nakahara Kazushige、Morokuma Seiichi、Maehara Kana、Okawa Hikohiro、Funabiki Yasuko、Kato Kiyoko
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1

    • DOI

      10.1038/s41598-022-12330-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants2022

    • Author(s)
      Nakahara Kazushige、Michikawa Takehiro、Morokuma Seiichi、et al.
    • Journal Title

      Communications Medicine

      Volume: 2 Issue: 1 Pages: 35-35

    • DOI

      10.1038/s43856-022-00101-y

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of maternal sleep before and during pregnancy with sleep and developmental problems in 1-year-old infants2021

    • Author(s)
      Nakahara Kazushige、Michikawa Takehiro、Morokuma Seiichi、et al.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-91271-7

    • NAID

      120007124578

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of physical activity before and during pregnancy on infant’s sleep and neurodevelopment at 1-year-old2021

    • Author(s)
      Nakahara Kazushige、Michikawa Takehiro、Morokuma Seiichi、et al.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-87612-1

    • NAID

      120007044567

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripartum depression and infant care, sleep and growth.2020

    • Author(s)
      Iwata S, Kinoshita M, Fujita F, Tsuda K, Unno M, Horinouchi T, Morokuma S, Saitoh S, Iwata O.
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 10186-10186

    • DOI

      10.1038/s41598-019-46563-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exposure to Asian dust within a few days of delivery is associated with placental abruption in Japan: a case‐crossover study2019

    • Author(s)
      Michikawa T、Yamazaki S、Shimizu A、Nitta H、Kato K、Nishiwaki Y、Morokuma S
    • Journal Title

      BJOG: An International Journal of Obstetrics & Gynaecology

      Volume: 127 Issue: 3 Pages: 335-342

    • DOI

      10.1111/1471-0528.15999

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simplified wide-Range ultrasonic measurements using the sensor three-Dimensional system2018

    • Author(s)
      Morokuma Seiichi、Maehara Kana、Okawa Hikohiro、Kato Kiyoko、Mine Yoshitaka、Nakauchi Shouichi
    • Journal Title

      Journal of Medical Ultrasound

      Volume: 26 Issue: 2 Pages: 100-102

    • DOI

      10.4103/jmu.jmu_17_18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-reassuring foetal status and neonatal irritability in the Japan Environment and Children’s Study: A cohort study2018

    • Author(s)
      Morokuma Seiichi、Michikawa Takehiro、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Senju Ayako、Kawamoto Toshihiro、Ohga Shouichi、Kusuhara Koichi
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 15853-15853

    • DOI

      10.1038/s41598-018-34231-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Neurological outcomes and their correlation to fetal behavior patterns2019

    • Author(s)
      Seiichi Morokuma
    • Organizer
      KSOG
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Tracking Fetal Development: New Modalities2019

    • Author(s)
      Seiichi Morokuma
    • Organizer
      the 26th Asia and Oceania Federation of Obstetrics and Gynecology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2024-01-30  

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