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The relationship between vulnerability to gambling and drug dependence and stress resilience in rats

Research Project

Project/Area Number 18H01097
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Yamada Kazuo  筑波大学, 人間系, 教授 (30282312)

Co-Investigator(Kenkyū-buntansha) 一谷 幸男  筑波大学, 人間系(名誉教授), 名誉教授 (80176289)
小澤 貴明  大阪大学, 蛋白質研究所, 助教 (90625352)
椙田 麻菜美  筑波大学, 人間系, 客員研究員 (70776765)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywordsラット / ギャンブル嗜好性 / 薬物依存 / ストレスレジリエンス / 個体差 / オプトジェネティックス / ギャンブル課題 / 背外側被蓋野 / オペラント行動 / ギャンブル依存
Outline of Final Research Achievements

We investigated the relationship between gambling-, drug-dependence, and stress resilience in rats. Our data showed that 1. there were individual differences in gambling behaviors in rats, 2. optogenetic inhibition of dorsolateral tegmental area decreased gambling behaviors, 3. There is a significant positive correlation between gambling behaviors and vulnerability to drug dependence.

Academic Significance and Societal Importance of the Research Achievements

人は誰もがギャンブル依存や薬物依存,心的外傷後ストレス障害になるわけではなく,そこには個人差が存在する。ラットでも人と同じような個体差が存在すること,さらにギャンブル依存と薬物依存が同じ脳内メカニズムによって生じることを明らかにした本研究の成果は,ギャンブル依存や薬物依存の治療だけでなく効果的な予防法の開発に繋がることが期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (23 results)

All 2020 2019 2018 Other

All Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 6 results) Presentation (14 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Remarks (3 results)

  • [Journal Article] Enhanced methamphetamine-induced conditioned place preference in risk-taking rats2020

    • Author(s)
      Takahashi Katsumasa、Toyoshima Michimasa、Ichitani Yukio、Yamada Kazuo
    • Journal Title

      Behavioural Brain Research

      Volume: 378 Pages: 112299-112299

    • DOI

      10.1016/j.bbr.2019.112299

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] D-Cycloserine reverses scopolamine-induced object and place memory deficits in a spontaneous recognition paradigm in rats2019

    • Author(s)
      Ozawa Takaaki、Yamada Kazuo、Ichitani Yukio
    • Journal Title

      Pharmacology Biochemistry and Behavior

      Volume: 187 Pages: 172798-172798

    • DOI

      10.1016/j.pbb.2019.172798

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Differential effects of N-methyl-D-aspartate receptor blockade during the second and third postnatal weeks on spatial working and reference memory in adult rats2019

    • Author(s)
      Furuie Hiroki、Yamada Kazuo、Ichitani Yukio
    • Journal Title

      Brain Research

      Volume: 1721 Pages: 146339-146339

    • DOI

      10.1016/j.brainres.2019.146339

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Social enrichment improves social recognition memory in male rats2018

    • Author(s)
      Toyoshima, M., Yamada, K., Sugita, M., & Ichitani, Y.
    • Journal Title

      Animal Cognition

      Volume: 21 Issue: 3 Pages: 345-351

    • DOI

      10.1007/s10071-018-1171-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Temporal order memory of the rat in spontaneous object recognition: Effects of number of items, exposure interval, and retention time2018

    • Author(s)
      Hatakeyama, T., Sugita, M., Yamada, K., & Ichitani, Y.
    • Journal Title

      Learning & Memory

      Volume: 25 Issue: 11 Pages: 574-579

    • DOI

      10.1101/lm.048215.118

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] げっ歯類における薬物・ギャンブル依存と意思決定プロセスの関係に関する研究の動向2018

    • Author(s)
      高橋克匡・一谷幸男・山田一夫
    • Journal Title

      筑波大学心理学研究

      Volume: 55 Pages: 1-8

    • NAID

      120006454823

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Acute social isolation increases rats’ social motivation toward their cage mates: Implications for a rodent model of a loneliness-like state.2020

    • Author(s)
      Toyoshima, M. & Yamada, K.
    • Organizer
      Tsukuba Global Science Week 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 孤独感のげっ歯類モデル確立に向けた試み:急性の社会的隔離がもたらす社会的動機づけの変化と関連脳領域の解析2020

    • Author(s)
      豊島理公・山田一夫
    • Organizer
      日本行動神経内分泌研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ラットの時間的順序記憶における内側前頭前野グルタミン酸受容体の役割2020

    • Author(s)
      椙田麻菜美・山田一夫・一谷幸男
    • Organizer
      日本生理心理学会第38回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of adenosine receptor antagonism on fear extinction in rats.2020

    • Author(s)
      Kaseda, K., Ozawa, T., Ichitani, Y. & Yamada, K.
    • Organizer
      日本神経科学会第43回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Hippocampal NMDA receptors are involved in non-spatial memory only under high memory load condition in rats.2019

    • Author(s)
      Yamada, K., Sugita, M., Iwamura, E. & Ichitani, Y.
    • Organizer
      The Third Sino-Japan Symposium on the Frontier of Behavioral Neuroendocrinology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hippocampal NMDA receptors are involved in non-spatial memory only under high memory load condition in rats.2019

    • Author(s)
      Yamada, K., Sugita, M., Iwamura, E. & Ichitani, Y.
    • Organizer
      TheThird Sino-Japan Symposium on the Frontier of Behavioral Neuroendocrinology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effects of dorsal hippocampal glutamate receptor blockade on rats’ temporal order memory in radial maze.2018

    • Author(s)
      Sugita, M., Takahashi, K., Yamada, K. & Ichitani, Y.
    • Organizer
      The 11th FENS Forum of Neuroscience
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhanced methamphetamine-induced conditioned place preference in risk-taking rats.2018

    • Author(s)
      Takahashi, K., Ichitani, Y. & Yamada, K.
    • Organizer
      Society for Neuroscience, 48th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Social enrichment enhances, while social isolation impairs, social recognition memory in male rats.2018

    • Author(s)
      Toyoshima, M., Sugita, M., Ichitani, Y. & Yamada, K.
    • Organizer
      Society for Neuroscience, 48th Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 背側海馬NMDA受容体拮抗薬投与がラットの自発的物体再認における時間順序記憶に及ぼす効果2018

    • Author(s)
      畠山太一・山田一夫・一谷幸男
    • Organizer
      日本神経精神薬理学会第48回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Temporal order memory acquisition in rats: Effect of training procedures.2018

    • Author(s)
      Sugita, M., Takahashi, K., Yamada, K., & Ichitani, Y.
    • Organizer
      日本動物心理学会第78回大会,
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットの自発的物体再認記憶に及ぼす内側前頭前野損傷の効果2018

    • Author(s)
      椙田麻菜美・山田一夫・一谷幸男
    • Organizer
      日本心理学会第82回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットにおける恐怖条件づけの消去に及ぼすMK-801/ D-cycloserine投与の影響―ストレスレジリエンスの違いによる比較―2018

    • Author(s)
      上野将玄・山田一夫・一谷幸男
    • Organizer
      日本生理心理学会第36回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ラットのストレスレジリエンスと物体・位置再認課題の関連2018

    • Author(s)
      上野将玄・山田一夫・一谷幸男
    • Organizer
      日本心理学会第82回大会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 筑波大学大学院人間総合科学学術院ニューロサイエンス学位プログラム行動神経科学グループ山田研究室

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 筑波大学大学院 人間総合科学研究科 感性認知脳科学専攻 行動神経科学分野 一谷・山田グループ

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 筑波大学人間総合科学研究科感性認知脳科学専攻 行動神経科学分野 一谷・山田グループ

    • URL

      http://www.kansei.tsukuba.ac.jp/~ichitanilab/

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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