| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
We aimed to elucidate the relationship between proton transfer mechanisms and protein structures involving H-bond networks in order to establish a method to predict proton transfer phenomena in proteins from a structural perspective. In photosystem II, which catalyzes the water-splitting and oxygen-evolving reactions in photosynthesis, the structural fluctuations of certain water molecules bound to the protein are sufficiently small, and the water molecules form a pathway that enables efficient proton transfer. In contrast, in aquaporins, which are water transport channel proteins, H-bonds between the water molecules and the protein are weak, resulting in large structural fluctuations of the water molecules. Consequently, aquaporins cannot maintain the H-bond network structure suitable for efficient proton transfer, resulting in the absence of the proton transfer ability.
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