| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Outline of Final Research Achievements |
Intracellular molecular diffusion is often anomalous. To elucidate the mechanism of this anomalous diffusion from the structural features, we mimicked the cell structure using cell-sized droplets of a highly concentrated polymer solution confined by a lipid membrane and analyzed the diffusion behavior. The results show that the anomalous diffusion depends only on the crowded environment produced by the polymer and not on the droplet radius. On the other hand, the diffusion coefficient decreases when the droplet radius becomes about 20 um, and the degree of decrease depends on the physical properties of the membrane covering the droplet. In the future, we will verify that the origin of the decrease in diffusion coefficient is the increase in molecular size due to the formation of molecular clusters or the change in the effective relaxation time of polymer chains.
|
