| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
|---|
| Outline of Final Research Achievements |
Cytoplasm forms glass when metabolic activities are lost, but the living cytoplasm maintains fluidity. Clearly, activeness of living systems profoundly affects their mechanical properties, but the underlying physical mechanism is largely unknown. That is because statistical mechanics common at thermodynamic equilibrium do not apply to living cytoplasm since it is driven out of equilibrium by the mechanical energy derived from metabolism. In this study, in order to elucidate the physical mechanism, we reproduced the phenomenon by creating an in vitro model that can control the non-equilibrium activity by exchanging the metabolites and byproducts. By conducting microrheology experiments, it was found that a suspension that exhibits biological turbulence fluidizes as the violation of the fluctuation-dissipation theorem is pronounced. Furthermore, it was found that even the thermal fluctuation at high frequencies is enhanced significantly with metabolic activities.
|
