| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Outline of Final Research Achievements |
In this study, we investigated the effects of simple peptides on ribozyme activity in order to recapitulate the coevolutionary pathway of ancient peptides and RNA. We demonstrated that even simple peptides such as KKVVVVVV were able to achieve functions such as self-assembly, RNA concentration, and ribozyme activation. In addition, we reconstructed the ancient protein structure preserved in the active center of RNA polymerase with short peptides, resulting in the reproduction of the ancient protein fold with only seven amino acid types. These seven amino acids are coded in a corner in the genetic code and are estimated to be the ancient genetic code.
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