Development of Nanobio terahertz measurement platform using local-terahertz-electric-field-enhanced metamaterial chips
| Project/Area Number |
18H01499
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 21060:Electron device and electronic equipment-related
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| Research Institution | Osaka University |
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Principal Investigator |
Serita Kazunori 大阪大学, レーザー科学研究所, 特任助教 (00748014)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | テラヘルツ / 非線形光学 / メタマテリアル / 局所テラヘルツ場 / 近接場テラヘルツ励起 / ファノ共鳴 / 微量分析 / 乳癌 / メタアトム / 光整流 / DNAメチル化 / タンパク質加水分解 / テラヘルツ分光 / ナノバイオ / 局所場光物性 / 局所テラヘルツ点光源 / バイオセンシング |
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| Outline of Final Research Achievements |
We have developed a micro- and high-intense point terahertz (THz) source using optical-THz conversion in a nonlinear optical crystal and applied it to the development of a novel THz measurement platform that operates based on near-field interaction between a sample and the THz source. Based on this idea, we have developed unique THz biosensors with a few arrays of asymmetric metamaterials and a THz near-field spectroscopic imaging system, with which femtomole order of the various solutes, such as ions, sugar, and proteins, can be sensed in picoliter-order solutions and early-stage cancers less than 0.5 mm in size can be visualized without staining. Establishing such a noninvasive, label-free, and highly sensitive THz measurement platform using trace amounts of biological samples would contribute greatly to nano-biosensing with THz waves and future medical societies as well as acquiring new biological knowledge.
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| Academic Significance and Societal Importance of the Research Achievements |
マイクロ化学チップ技術が飛躍的な発展を遂げたように、THz領域においてもチップ開発や高感度なバイオ計測手法の開発が羨望されている。その大きな問題となっているTHzバイオ計測時の感度低下と空間分解能の問題が本研究によって解決され、非侵襲・非標識での全く新しい診断・分析技術の提供が行えるようになる。本研究成果は、THz波を利用したナノバイオ計測の実現可能性に資する重要な成果であり、今後のバイオ・医療分野への応用展開と新しい生物学的知見取得に期待できる。
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Report
(4 results)
Research Products
(56 results)
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[Presentation] Near-Field Terahertz Imaging of Ductal Carcinoma In Situ (DCIS) of the Breast2020
Author(s)
K. Okada, K. Serita, Z. Zang, H. Murakami, I. Kawayama, Q. Cassar, G. MacGrogan, J. Guillet, P. Mounaix, M. Tonouchi
Organizer
The 81th Autumn Meeting, JSAP-OSA Joint Symposia 2020
Related Report
Int'l Joint Research
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[Presentation] Exciton Dynamics in Semiconducting Carbon Nanotubes Probed by Terahertz Emission and Photocurrent Spectroscopy2020
Author(s)
F. R. G. Bagsican, M. Wais, N. Komatsu, W. Gao, K. Serita, H. Murakami, K. Held, I. Kawayama, J. Kono, M. Tonouchi, M. Battiato
Organizer
The 81th Autumn Meeting, JSAP-OSA Joint Symposia 2020
Related Report
Int'l Joint Research
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[Presentation] Observation of Bi2Te3/Te striped structures using a laser terahertz emission microscope2019
Author(s)
F. Murakami, K. Serita, H. Murakami, R. Dalipi, A. M. Urbas, A. Materna, M. Buza, D. A. Pawlak, M. Tonouchi, I. Kawayama
Organizer
44th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz 2019)
Related Report
Int'l Joint Research
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[Presentation] Characteristics of THz emissions from Bi2Te3/Te striped structure2019
Author(s)
F. Murakami, K. Serita, H. Murakami, R. Dalipi, A. M. Urbas, A. Materna, M. Buza, D. A. Pawlak, M. Tonouchi, I. Kawayama
Organizer
The 21st International Conference on Electron Dynamics in Semiconductors, Optoelectronics and Nanostructures (EDISON2019)
Related Report
Int'l Joint Research
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[Presentation] Development of a Scanning Near-field Terahertz Reflection Microscope for Highly Sensitive Bio-sensing2019
Author(s)
K. Okada, K. Serita, Z. Zang, H. Murakami, I. Kawayama, Q. Cassar, A. Al-Ibadi, G. MacGrogan, T. Zimmer, J. Guillet, P. Mounaix, M. Tonouchi
Organizer
International Workshop on Optical Terahertz Science and Technology (OTST 2019)
Related Report
Int'l Joint Research
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[Presentation] Terahertz emission from photoconductive antenna switches based on highly-aligned and chirality-enriched semiconducting carbon nanotubes2019
Author(s)
F. R. G. Bagsican, I. Kawayama, M. Wais, N. Komatsu, K. Serita, W. Gao, L. Weber, M. Battiato, H. Murakami, F. A. Hegmann, J. Kono, M. Tonouchi
Organizer
International Workshop on Optical Terahertz Science and Technology (OTST 2019)
Related Report
Int'l Joint Research
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[Presentation] Scanning laser terahertz near-field reflection microscope for biological analysis2019
Author(s)
K. Okada, K. Serita, Z. Zang, H. Murakami, I. Kawayama, Q. Cassar, A. Al-Ibadi, G. MacGrogan, T. Zimmer, J. Guillet, P. Mounaix, M. Tonouchi
Organizer
OSA Biophotonics Congress
Related Report
Int'l Joint Research
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[Presentation] Terahertz emission properties of photoconductive antennas based on semiconducting carbon nanotubes2018
Author(s)
F. R. Bagsican, I. Kawayama, K. Serita, W. Gao, N. Komatsu, M. Wais, L. Weber, M. Battiato, H. Murakami, F. A. Hegmann, J. Kono, and M. Tonouchi
Organizer
The Global Nanophotonics 2018 (GNP 2018)
Related Report
Int'l Joint Research
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