• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Occurrence of antibiotic resistant bacteria producing extended-spectrum beta-lactamase in water environment and reduction of resistant bacteria by wastewater treatment

Research Project

Project/Area Number 18H01568
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 22060:Environmental systems for civil engineering-related
Research InstitutionEhime University

Principal Investigator

Yamashita Naoyuki  愛媛大学, 農学研究科, 教授 (90391614)

Co-Investigator(Kenkyū-buntansha) 田中 宏明  京都大学, 工学研究科, 教授 (70344017)
井原 賢  京都大学, 工学研究科, 特定助教 (70450202)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywords薬剤耐性菌 / 基質特異性拡張型βラクタマーゼ / 水環境 / 大腸菌 / 大腸菌群 / 多剤耐性
Outline of Final Research Achievements

The occurrence of antibiotic resistant bacteria producing extended-spectrum β-lactamase (ESBL) in the water environment was surveyed in this research. The removal of the ESBL producing bacteria in the wastewater treatment plant (WWTP) was also determined to evaluate effective water treatment processes in the WWTP for the control of the ESBL bacteria in water. Since the resistant patterns of the ESBL bacteria against antibiotics used in medical field provide the important information to treat infectious diseases, the resistant profiles of the ESBL bacteria isolated from the water environment and the antibiotic resistant genes of the ESBL were determined in this research.

Academic Significance and Societal Importance of the Research Achievements

本研究では,水環境中におけるESBL産生耐性菌の存在実態を明らかするとともに,水中のESBL産生耐性菌を低減するために有効な水処理プロセスについて考察している。本研究は,水環境中に存在するESBL産生耐性菌を制御するために有用な知見を提供しており,社会的意義のある成果が得られている。また,水環境中に存在するESBL産生耐性菌の各種抗菌薬に対する薬剤耐性を明らかにすることにより,ESBL産生耐性菌による感染症に対する経験的治療(empiric therapy)を行う上で有用なデータを提供しており,学術的意義のある成果が得られている。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (21 results)

All 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] 琵琶湖南東部の河川における大腸菌とその薬剤耐性の存在実態2021

    • Author(s)
      杉江由規,井原賢,馬緻宇,田中宏明
    • Journal Title

      環境衛生工学研究

      Volume: 35 Pages: 29-35

    • NAID

      40022541335

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] THE OCCURRENCE OF ANTIMICROBIAL RESISTANT <i>E. COLI</i> AND EFFECTS OF RAINFALL IN THE RIVESRS OF SOUTH-EAST WATERSHED OF THE LAKE BIWA2020

    • Author(s)
      杉江由規,井原賢,馬緻宇,田中宏明
    • Journal Title

      Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research)

      Volume: 76 Issue: 7 Pages: III_431-III_440

    • DOI

      10.2208/jscejer.76.7_III_431

    • NAID

      130007999707

    • ISSN
      2185-6648
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ESTIMATION OF MICROBIAL LOAD DISCHARGED FROM A SEWAGE TREATMENT PLANT TO RECEIVING WATERS2020

    • Author(s)
      西田光希,張浩然,井原賢,田中宏明
    • Journal Title

      Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research)

      Volume: 76 Issue: 7 Pages: III_441-III_448

    • DOI

      10.2208/jscejer.76.7_III_441

    • NAID

      130007999711

    • ISSN
      2185-6648
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 雨天時の都市下水中の衛生微生物と溶存態有機物の動態比較2020

    • Author(s)
      山口武志,山下尚之,林東範,井原賢,田中宏明
    • Journal Title

      環境衛生工学研究

      Volume: 34 Pages: 12-20

    • NAID

      40022218228

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] THE EFFECT OF SANITARY SEWER OVERFLOW DURING RAINY EVENTS ON THE BEHAVIOR OF DISSOLVED ORGANIC MATTERS AND SANITARY MICROORGANISMS IN WATER OF THE RIVER FLOWING OUT OF LAKE BIWA2019

    • Author(s)
      山口武志,山下尚之,田村太一,田中宏明
    • Journal Title

      Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research)

      Volume: 75 Issue: 7 Pages: III_185-III_198

    • DOI

      10.2208/jscejer.75.7_III_185

    • NAID

      130007814683

    • ISSN
      2185-6648
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「Swimmable」な水環境管理目標の 改定と課題2018

    • Author(s)
      田中宏明
    • Journal Title

      環境衛生工学研究

      Volume: 32 Pages: 3-8

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 下水道における水系水質リスクの管理2018

    • Author(s)
      田中宏明
    • Journal Title

      下水道協会誌

      Volume: 55 Pages: 667-667

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A STUDY ON THE EFFECT OF MUNICIPAL WASTEWATER IN WET WEATHER ON THE DYNAMICS OF DISSOLVED ORGANIC MATTER IN RIVER WATER BY USING EEM-PARAFAC2018

    • Author(s)
      山口武志,山下尚之,田中宏明
    • Journal Title

      Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research)

      Volume: 74 Issue: 7 Pages: III_275-III_284

    • DOI

      10.2208/jscejer.74.III_275

    • NAID

      130007627352

    • ISSN
      2185-6648
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 琵琶湖南東部の河川における大腸菌とその薬剤耐性の存在実態2020

    • Author(s)
      杉江由規,井原賢,馬緻宇,田中宏明
    • Organizer
      第42回京都大学環境衛生工学研究会シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 雨天時の下水処理場から放流先水域に排出される微生物負荷量の推定および塩素消毒効果の検討2020

    • Author(s)
      西田光希,張浩然,西田佳記,井原賢,田中宏明
    • Organizer
      第54回日本水環境学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 雨天時の都市下水中の溶存態有機物と衛生微生物の動態比較2019

    • Author(s)
      山口武志,山下尚之,林東範,井原賢,田中宏明
    • Organizer
      第41回京都大学環境衛生工学研究会シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Genetic characteristics of ampicillin-resistant E. coli in wastewater treatment plants influent, effluent, and Lake Biwa2019

    • Author(s)
      Chih-Yu Ma, Masaru Ihara, Siyao Liu, Hiroaki Tanaka
    • Organizer
      第 22 回日本水環境学会シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 琵琶湖流出河川水中の溶存態有機物と衛生微生物の動態へ及ぼす雨天時都市下水の影響調査2019

    • Author(s)
      山口武志,山下尚之,田村太一,田中宏明
    • Organizer
      第56回環境工学研究フォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Antimicrobial Resistance Profiles among Escherichia Coli Strains Isolated from Lake Biwa and Wastewater Treatment Plants Effluent Revealed by Whole-genome Sequencing Analysis2019

    • Author(s)
      Chih-Yu Ma, Masaru Ihara, Siyao Liu, Yoshiki Okuno, Yu Zaizhi, Taichi Tamura, Naoyuki Yamashita, Hiroaki Tanaka
    • Organizer
      The 28th KAIST-KU-NTU-NUS (KKNN) Symposium on Environmental Engineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Four-year monthly survey of norovirus GII in the southern part of Lake Biwa, Japan2019

    • Author(s)
      Zaizhi Yu, Yoshiki Okuno, Yuya Shirasaka, Taichi Tamura, Akihiko Hata, Dongbum Im, Takeshi Yamaguchi, Masaru Ihara, Naoyuki Yamashita, Hiroaki Tanaka
    • Organizer
      The 5th Asian Symposium on Water Reuse -Technology Renovation and Risk Management
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Higher occurrence of norovirus GII during summer and autumn in the southern part of Lake Biwa, Japan2019

    • Author(s)
      Zaizhi Yu, Yoshiki Okuno, Yuya Shirasaka, Taichi Tamura, Akihiko Hata, Dongbum Im, Takeshi Yamaguchi, Masaru Ihara, Naoyuki Yamashita, Hiroaki Tanaka
    • Organizer
      20th International Symposium on Health- Related Water Microbiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Impacts assessment of WWTPs effluent on antimicrobial resistance dissemination of receiving aquatic ecosystem in Japan by whole-genome sequencing approach2019

    • Author(s)
      Chih-Yu Ma, Masaru Ihara, Siyao Liu, Taichi Tamura, Dongbum Im, Naoyuki Yamashita, Hiroaki Tanaka
    • Organizer
      20th International Symposium on Health- Related Water Microbiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] EEM-PARAFACを用いた雨天時の桂川における下水処理放流水混入の簡易指標に関する検討2018

    • Author(s)
      山口武志,山下尚之,田中宏明
    • Organizer
      第40回京都大学環境衛生工学研究会シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 蛍光分析を活用した処理場での雨天時下水中の溶存有機成分の挙動特性に関する検討2018

    • Author(s)
      山口武志,山下尚之,田中宏明
    • Organizer
      第55回下水道研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 雨天時の下水処理場における指標微生物の制御に関する基礎検討2018

    • Author(s)
      松葉祐亮,田中景介,西田佳記,山下尚之,田中宏明
    • Organizer
      第30回環境システム計測制御学会研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 河川の衛生学的安全性へ及ぼす雨天時下水の影響2018

    • Author(s)
      山口武志,林東範,井原賢,田中宏明
    • Organizer
      第21回日本水環境学会シンポジウム
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi