| Project/Area Number |
18H01575
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 22060:Environmental systems for civil engineering-related
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| Research Institution | National Institute of Public Health |
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Principal Investigator |
Simazaki Dai 国立保健医療科学院, その他部局等, 上席主任研究官 (60322046)
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| Co-Investigator(Kenkyū-buntansha) |
春日 郁朗 東京大学, 大学院工学系研究科(工学部), 准教授 (20431794)
秋葉 道宏 国立保健医療科学院, その他部局等, 主任研究官 (00159336)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | エンドトキシン / 水道 / 浄水処理 / 生物活性炭 / 微生物群集構造 |
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| Outline of Final Research Achievements |
Endotoxin (ET) is found in the extracellular membrane of Gram-negative bacteria, which are common in the water environment. ET is a physiologically active substance that could cause various adverse health impacts to human when it enters the human body through blood and is of increasing concern among medical professionals conducting dialysis therapies. In this study, we examined the behavior of ET activity in the course of advanced water purification process at several domestic water treatment plants, and also evaluated the ET producing capacity/characteristics of several bacterium isolated from biological activated carbon samples. As an outcome of this study, we identified several high ET-producing bacteria groups in biological activated carbon and their ET-producing ability/characteristics, clarified ET removal capability of each water treatment process, and the possibility of controlling ET by operating conditions of key water treatment processes.
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| Academic Significance and Societal Importance of the Research Achievements |
生物活性炭ろ過においてエンドトキシン産生の中心となる細菌群を同定し、水処理プロセスでの挙動を考慮した制御方法の提案をめざす点で有用性が高い。また、生物活性炭の水質変換機能と群集構造とを関連づける国内外の諸研究の中で、当研究成果はエンドトキシン産生に寄与する細菌を対象としており、新規性ならびに独創性が高い。当研究の成果は、水道水および医療用水の安全性と信頼性のさらなる向上に資することが期待される。
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