• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The Study of Nucleation Phenomena at the Template Interface and the Application for Production of Uniform Crystalline Particles

Research Project

Project/Area Number 18H01765
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 27010:Transport phenomena and unit operations-related
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Takiyama Hiroshi  東京農工大学, 工学(系)研究科(研究院), 教授 (40251582)

Co-Investigator(Kenkyū-buntansha) 工藤 翔慈  群馬工業高等専門学校, 物質工学科, 助教 (50735008)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywords鋳型界面 / 核化 / 共結晶 / 晶析 / 異相界面 / 粒径分布 / 結晶多形
Outline of Final Research Achievements

In the production of crystalline chemical products, crystalline particles with the desired size and monodispersity are required. For this purpose, precise control of nucleation is essential. In this study, the template interface developed at the air-liquid interface was used. By resetting the interface by heating, the local supersaturation was successfully retained, and the number of nucleation could be controlled. Nucleation control is also important issue in multicomponent co-crystal production. As a result of the control of nucleation for co-crystals, the relationship between nucleation and crystal quality, such as the uniformity of crystalline particles, was also clarified.

Academic Significance and Societal Importance of the Research Achievements

結晶化プロセスの核化はその後の成長にも影響するため、より精密な制御が要求される。鋳型界面には、核化トリガーの機能が備わっており、その機能を充分に発揮できるような操作法を見いだすことが必要である。そこで、鋳型界面上に局所的に限定させた過飽和を実現させることで、核化数の制御に成功した。核化や核化数の制御は均一な品質を有した結晶粒子群製造に必須の技術であり、本研究の結果によって結晶化の推進力と核化制御による結晶粒子群の均一性との関係を整理できた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (12 results)

All 2020 2019 2018

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results) Presentation (6 results) (of which Invited: 3 results)

  • [Journal Article] Development of novel cascade type crystallizer for continuous production of crystalline particles2020

    • Author(s)
      Koyama Mana、Kudo Shoji、Amari Shuntaro、Takiyama Hiroshi
    • Journal Title

      Journal of Industrial and Engineering Chemistry

      Volume: 89 Pages: 111-114

    • DOI

      10.1016/j.jiec.2020.06.021

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increase of solidification rate to improve quality of productivity for xylitol/sorbitol crystalline candy products2020

    • Author(s)
      Atsukawa Kentaro、Kudo Shoji、Amari Shuntaro、Takiyama Hiroshi
    • Journal Title

      Journal of Food Engineering

      Volume: 268 Pages: 109738-109738

    • DOI

      10.1016/j.jfoodeng.2019.109738

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Effect of Initial Temperature and Slurry Density on Stable Crystallization Process of Xylitol Melt Containing Sorbitol2020

    • Author(s)
      Otgonnyam Gemgui、Kamakura Yoshimitsu、Kudo Shoji、Takiyama Hiroshi
    • Journal Title

      Food Science and Technology Research

      Volume: 26 Issue: 2 Pages: 235-238

    • DOI

      10.3136/fstr.26.235

    • NAID

      130007849669

    • ISSN
      1344-6606, 1881-3984
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystal Quality Control by Using the Millimeter-Size Tube Type Taylor Vortex Continuous Crystallizer2019

    • Author(s)
      Yamaguchi Yuko、Kim Woo-Sik、Takiyama Hiroshi
    • Journal Title

      JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

      Volume: 52 Issue: 3 Pages: 308-310

    • DOI

      10.1252/jcej.18we024

    • NAID

      130007616812

    • ISSN
      0021-9592, 1881-1299
    • Year and Date
      2019-03-20
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Production of crystalline particles with high homogeneity in reaction crystallization by using pH-solubility-profile2019

    • Author(s)
      Ohyama Mitsuki、Kudo Shoji、Amari Shuntaro、Takiyama Hiroshi
    • Journal Title

      Journal of Industrial and Engineering Chemistry

      Volume: 75 Pages: 38-43

    • DOI

      10.1016/j.jiec.2019.03.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the Change in Morphology of Glycine Crystalline Particles at the Template Interface with L-Leucine2018

    • Author(s)
      Suzuki Haruka、Takiyama Hiroshi
    • Journal Title

      JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

      Volume: 51 Issue: 3 Pages: 276-281

    • DOI

      10.1252/jcej.17we206

    • NAID

      130006516168

    • ISSN
      0021-9592, 1881-1299
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高品質な結晶粒子群製造のための晶析操作設計の展開2020

    • Author(s)
      滝山 博志
    • Organizer
      化学工学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Effect of Two Kinds of Supersaturation on Crystal Qualities during Cocrystallization2020

    • Author(s)
      滝山 博志
    • Organizer
      化学工学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 溶液晶析法による共結晶粒子群のHomogeneity評価2020

    • Author(s)
      大山 満希・甘利 俊太朗・滝山 博志
    • Organizer
      化学工学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ソフトテンプレート上に析出する結晶粒子群の凝集現象2019

    • Author(s)
      谷 翔子・甘利 俊太朗・滝山 博志
    • Organizer
      分離技術会 年会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Anti-Solvent添加晶析での結晶粒子群品質とその制御に対する操作戦略2019

    • Author(s)
      滝山博志
    • Organizer
      化学工学会第84年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高品質な結晶粒子群製造のための晶析プロセス操作設計2018

    • Author(s)
      滝山博志
    • Organizer
      化学工学会第50回秋季大会
    • Related Report
      2018 Annual Research Report
    • Invited

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi