Flow process of bioadhesive liposome production using supercritical-segmented solution
| Project/Area Number |
18H01773
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 27020:Chemical reaction and process system engineering-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 超臨界二酸化炭素 / フロープロセス / リポソーム / 微小流路 / リポソーム形成 / 超臨界流体 / 相分離 / スラグ流 / マイクロ流路 |
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| Outline of Final Research Achievements |
Flow-type fabrication method of liposome was developed by using flow state of supercritical carbon dioxide in microfluid system. This flow-type process was extended to the fabrication of PEGylated liposome. It is found that the structured-liposome can be formed in this flow-type process. Size of liposome can be controlled largely using ethanol as solvent for lipid in the flow-type process. Also, the fabrication process of PEGylated liposome in Post-Tube process allows to reduce the particle size of liposome and increase the encapsulation efficiency compared with those by the batch-type process.
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| Academic Significance and Societal Importance of the Research Achievements |
超臨界二酸化炭素を利用することで，人体に有害となる有機溶媒の使用量を大幅に低減でき，かつ連続的なリポソームの生成プロセスを構築した点は，安全かつ低価格な医薬品，化粧品の製造への応用が期待され，社会的な意義がある．本研究課題における微小流路での流動状態，ならびに微量流路におけるリポソームの構造化は，超臨界二酸化炭素の新たな技術展開として学術的意義がある．
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Report
(4 results)
Research Products
(16 results)
