| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
In this study, we have developed a new intracellular protein-protein interaction detection technology that detects cell proliferation associated with intracellular protein-protein interactions using a receptor or a signaling molecule downstream of receptors. In this method, the detection sensitivity of protein-protein interactions could be adjusted by adding a small molecule. Using this method, peptide-protein domain interactions could be detected generally, and high-affinity intracellular antibodies could be screened from a library.
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