Development of sophisticated biosynthetic process for magnetic nanoparticles by using intracellular compartment
Project/Area Number |
18H01794
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 27040:Biofunction and bioprocess engineering-related
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Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
Arakaki Atsushi 東京農工大学, 工学(系)研究科(研究院), 准教授 (10367154)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
|
Keywords | 磁性ナノ粒子 / コンパートメント / バイオプロセス / 遺伝子組換え / 細菌 / バイオミネラリゼーション / 遺伝子発現制御 / 生体機能利用 / ナノ材料合成 / 反応プロセス制御 |
Outline of Final Research Achievements |
In this study, the regulation of manufacturing process for magnetic nanoparticles was investigated by using compartment in genetically modified magnetotactic bacteria. The method for introduction of large DNA fragment into the genome of magnetotactic bacteria was established. Control of shape, size and number of magnetic particles were shown by designing introduced gene sets or regulating gene expressions. Moreover, composition of magnetic particles was modified by the expression of metal ion transporter gene in the cell.
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Academic Significance and Societal Importance of the Research Achievements |
本研究では、磁性細菌の遺伝子を設計することで、磁気微粒子の形態・サイズ・組成と磁気特性の制御が可能であることを示した。遺伝子やゲノムに基づいてバイオプロセスを設計し、無機結晶合成を制御した世界初の例である。今後、酸化鉄磁気微粒子のみならず多様な無機結晶のバイオ合成法の開発に繋がる可能性があり、学術的・社会的に意義のある成果である。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Radular Stylus of Cryptochiton Stelleri: A Multifunctional Lightweight and Flexible Fiber-Reinforced Composite2020
Author(s)
Anna Pohl, Steven A. Herrera, David Restrepo, Ryo Negishi, Jae-Young Jung, Chris Salinas, Richard Wuhrer, Tomoko Yoshino, Joanna McKittrick, Atsushi Arakaki, Michiko Nemoto, Pablo Zavattieri, David Kisailus
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Journal Title
J Mech Behav Biomed Mater
Volume: 111
Pages: 103991-103991
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Crystallization by particle attachment is a colloidal assembly process2020
Author(s)
Mirabello, G, Ianiro, A, Bomans, PHH, Yoda, T, Arakaki, A, Friedrich, H,de With, G, Sommerdijk, NAJM
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Journal Title
NATURE MATERIALS
Volume: 19
Issue: 4
Pages: 391-396
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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