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Synthesis and Virus Capture of Self-Propelled Protein Microtube Motors by Bubble Jetting of Enzyme Reaction

Research Project

Project/Area Number 18H01833
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 28030:Nanomaterials-related
Research InstitutionChuo University

Principal Investigator

KOMATSU Teruyuki  中央大学, 理工学部, 教授 (30298187)

Co-Investigator(Kenkyū-buntansha) 森田 能次  中央大学, 理工学部, 助教 (40795308)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Keywordsタンパク質 / カタラーゼ / ウレアーゼ / 大腸菌 / ウイルス / 酵素 / 金ナノ粒子 / マイクロチューブ / 交互積層 / ヘマグルチニン / アビジンービオチン / 自己攪拌能 / アビジン-ビオチン / 酵素活性 / 自走能
Outline of Final Research Achievements

We have synthesized microtube (MT) motors with a cylindrical hollow structure consisting of proteins. The MT with catalase on the inner surface was self-propelled by jetting oxygen bubbles generated by the disproportionation of hydrogen peroxide. The MT with urease interior surface was self-propelled by ejection of the product generated by the decomposition of urea. Furthermore, the MT motors coated with concanavalin A captured Escherichia coli. The MT motors coated with α-glucosidase acted as a self-stirring catalyst. The MT motor coated with fetuin captured efficiently the spike protein of influenza virus. In addition, the self-propelling velocity of MT coated with gold nanoparticles increased by light irradiation.

Academic Significance and Societal Importance of the Research Achievements

酵素反応を駆動力源として自走する蛋白質MTモーターの一群を合成し、それらの機能を明らかにした。得られた成果は、生体適合性に優れた薬物キャリアー、バイオコンテナー、病原体クリーナー、バイオ分子マシンなど、様々な新規生体機能材料の創出につながると考えられる。薬物送達システムの分子設計に新たな指針を与えるばかりでなく、バイオマテリアル化学に新領域を拓くものと期待される。人類の健康・福祉にもたらす波及効果と意義もきわめて大きい。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (34 results)

All 2020 2019 2018 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results) Presentation (17 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Remarks (9 results)

  • [Journal Article] Supramolecular Linear Coordination Polymers of Human Serum Albumin and Haemoglobin2020

    • Author(s)
      R. Adachi, S. Suzuki, T. Mitsuda, Y. Morita, T. Komatsu
    • Journal Title

      Chem. Commun.

      Volume: 56 Issue: 99 Pages: 15585-15588

    • DOI

      10.1039/d0cc07167f

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein-Based Smart Microtubes and Nanotubes as Ultrasmall Biomaterials2020

    • Author(s)
      T. Komatsu
    • Journal Title

      Chem. Lett.

      Volume: 49 Issue: 10 Pages: 1245-1255

    • DOI

      10.1246/cl.200433

    • NAID

      130007923180

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 水中で自走するタンパク質マイクロチューブモーター2020

    • Author(s)
      小松晃之
    • Journal Title

      高分子

      Volume: 69 Pages: 478-479

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonbubble-Propelled Biodegradable Microtube Motors Consisting Only of Protein2019

    • Author(s)
      N. Sugai, Y. Morita, T. Komatsu
    • Journal Title

      Chem. Asian J.

      Volume: 14 Issue: 17 Pages: 2953-2957

    • DOI

      10.1002/asia.201900927

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Microtube Motors with a Pt Nanoparticle Interior and Avidin Exterior for Self-Propelled Transportation, Separation, and Stirring2019

    • Author(s)
      Y. Nakai, N. Sugai, H. Kusano, Y. Morita, T. Komatsu
    • Journal Title

      ACS Appl. Nano Mater.

      Volume: 2 Issue: 8 Pages: 4891-4899

    • DOI

      10.1021/acsanm.9b00850

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酵素反応で自走する蛋白質マイクロチューブモーター -バイオメディカル領域での応用を目指して2019

    • Author(s)
      小松晃之、菅井夏穂
    • Journal Title

      化学

      Volume: 74 Pages: 66-67

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Stratiform Protein Microtube Reactors Containing Glucose Oxidase Layer2018

    • Author(s)
      R. Adachi, M. Akiyama, Y. Morita, T. Komatsu
    • Journal Title

      Chem. Asian J.

      Volume: 13 Issue: 19 Pages: 2796-2799

    • DOI

      10.1002/asia.201800927

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transparent Protein Microtube Motors with Controllable Velocity and Biodegradability2018

    • Author(s)
      N. Sugai, Y. Nakai, Y. Morita, T. Komatsu
    • Journal Title

      ACS Appl. Nano Mater.

      Volume: 1 Issue: 7 Pages: 3080-3085

    • DOI

      10.1021/acsanm.8b00791

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 蛋白質を用いた機能分子システムの創製と応用2020

    • Author(s)
      小松晃之
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 金ナノ粒子で被覆したカタラーゼマイクロチューブモーターの合成と光照射による速度制御2020

    • Author(s)
      菅原智直、加藤 遼、森田能次、小松晃之
    • Organizer
      日本化学会第101春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アゾベンゼン-ポリアクリル酸で被覆した蛋白質マイクロチューブモーターの合成とシクロデキストリン捕捉2020

    • Author(s)
      内藤圭吾、加藤 遼、森田能次、小松晃之
    • Organizer
      第10回CSJ化学フェスタ2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自己攪拌型酵素マイクロチューブモーターの合成2020

    • Author(s)
      梅原瑞希、加藤 遼、森田能次、小松晃之
    • Organizer
      第10回CSJ化学フェスタ2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自己攪拌能を有するα-グルコシダーゼマイクロチューブモーターの合成2020

    • Author(s)
      梅原瑞希、菅井夏穂、森田能次、小松晃之
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ポリアクリル酸で被覆した蛋白質マイクロチューブモーターの合成と機能2020

    • Author(s)
      内藤圭吾、菅井夏穂、森田能次、小松晃之
    • Organizer
      日本化学会第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 大腸菌捕捉能を有するレクチン/カタラーゼマイクロチューブモーターの合成2019

    • Author(s)
      菅井夏穂、森田能次、小松晃之
    • Organizer
      第9回CSJ化学フェスタ2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] ビスマレイミド架橋剤で連結したヘモグロビンオリゴマーの合成と酸素結合能2019

    • Author(s)
      高橋大輝、森田能次、小松晃之
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] バクテリア捕集能を有するカタラーゼマイクロチューブモーターの合成2019

    • Author(s)
      菅井夏穂、森田能次、小松晃之
    • Organizer
      第68回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Synthesis of Catalase Microtube Motors with Controllable Velocity and Biodegradability(ポスター賞受賞)2019

    • Author(s)
      N. Sugai, T. Komatsu
    • Organizer
      International Conference on Materials Science and Engineering (Materials Oceania)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-Propelled Protein Microtube Motors2019

    • Author(s)
      T. Komatsu
    • Organizer
      IUPAC 18th International Symposium on MacroMolecular Complexes (MMC-18)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Self-Propelled Microtube Motors Consisting of Proteins2019

    • Author(s)
      T. Komatsu
    • Organizer
      The 12th East Asian Symposium on Polymers for Advanced Technology (EASPAT 2017)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 外表面をアビジンで被覆した蛋白質マイクロチューブモーターの合成と機能2018

    • Author(s)
      菅井夏穂、中井葉子、森田能次、小松晃之
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 透明な蛋白質マイクロチューブモーターの合成と自走能制御2018

    • Author(s)
      菅井夏穂、森田能次、小松晃之
    • Organizer
      第27回ポリマー材料フォーラム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Gold-Nanoparticle Nanotubes Loaded Liposomes Encapsulating Anticancer Drug Doxorubicin2018

    • Author(s)
      Y. Enomoto, Y. Morita, T. Komatsu
    • Organizer
      IUPAC 14th International Conference on Novel Materials and their Synthesis (NMS-XIV)
    • Related Report
      2018 Annual Research Report
  • [Presentation] Self-Propelled Soft Protein Microtubes2018

    • Author(s)
      T. Komatsu
    • Organizer
      IUPAC 14th International Conference on Novel Materials and their Synthesis (NMS-XIV)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 水中で自走するカタラーゼマイクロチューブの合成(優秀ポスター賞受賞)2018

    • Author(s)
      菅井夏穂、中井葉子、森田能次、小松晃之
    • Organizer
      第67回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 中央大学理工学部 生命分子化学研究室ホームページ(日本語版・英語版)

    • URL

      https://komatsu-lab.r.chuo-u.ac.jp/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 本成果の論文が Chem. Lett. 誌の表紙と中表紙を飾りました

    • URL

      https://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2020/10/51244/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 研究協力者(大学院生)が Materials Oceania でポスター賞を受賞しました

    • URL

      https://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2019/09/45549/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 本成果の論文が Chem. Asian J. 誌のVIPに選ばれました

    • URL

      https://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2019/09/45322/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 本成果の論文が ACS Appl. Nano Mater. 誌の表紙を飾りました

    • URL

      https://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2019/08/45196/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 中央大学理工学部 生命分子化学研究室ホームページ(日本語版・英語版)

    • URL

      http://c-faculty.chuo-u.ac.jp/~komatsu/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究協力者(大学院生)が第27回ポリマー材料フォーラムで招待発表を行いました

    • URL

      https://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2018/11/15195/?r=1

    • Related Report
      2018 Annual Research Report
  • [Remarks] 本成果の論文が ACS Appl. Nano Mater. 誌の表紙を飾りました

    • URL

      https://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2018/07/15188/?r=1

    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究協力者(大学院生)が第67回高分子学会年次大会において優秀ポスター賞を受賞

    • URL

      https://www.chuo-u.ac.jp/academics/faculties/science/departments/chemistry/news/2018/06/15186/?r=1

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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