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Ultra-sensitive real-time MRS probe using high-field MRI

Research Project

Project/Area Number 18H01841
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 28050:Nano/micro-systems-related
Research InstitutionTottori University (2019-2020)
Tohoku University (2018)

Principal Investigator

MATSUNAGA Tadao  鳥取大学, 工学部, 准教授 (00396540)

Co-Investigator(Kenkyū-buntansha) 吉岡 芳親  大阪大学, 生命機能研究科, 特任教授(常勤) (00174897)
芳賀 洋一  東北大学, 医工学研究科, 教授 (00282096)
藤原 俊朗  岩手医科大学, 医学部, 助教 (60405842)
鶴岡 典子  東北大学, 工学研究科, 助教 (70757632)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
KeywordsMRI / MRS / MEMS / リアルタイムバイオイメージング / 非平面微細加工技術 / 体腔内MRIプローブ / Intraluminal MRI / MRSプローブ / 高磁場MRI
Outline of Final Research Achievements

An intraluminal magnetic resonance imaging (MRI) probe holds promise to achieve a higher resolution image of a small pathological lesion than conventional external probes. Such an intraluminal probe requires precise resonant frequency tuning to 500 MHz and impedance matching to 50 Ω, if used for instance in a 11.7-T scanner which can realize a real-time bio-imaging. Designed coil which has higher self-resonance frequency has been fabricated utilizing our developed non-planar photofabrication techniques, and an electrical characteristic has been evaluated. Measured self-resonant frequency of the MRI coil was around 800 MHz and it is higher enough to realize a higher resolution MRI.

Academic Significance and Societal Importance of the Research Achievements

当該研究により実現できる超高分解能なMRIはこれまで解明できていない体内深部における早期がんの発見につながるだけでなく、生体の神経活動などリアルタイムバイオイメージングの実現にもつながる。この様に医療デバイスだけでなく、生体内部における生理学的な減少を解明する取組であり、非平面微細加工技術や小型実装技術がブレークスルー技術である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (12 results) (of which Int'l Joint Research: 6 results,  Invited: 3 results)

  • [Journal Article] Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats.2020

    • Author(s)
      Fujiwara S., *Mori Y., **de la Mora D.M., Akamatsu Y., Yoshida K., *Shibata Y., Masuda T., Ogasawara K., *Yoshioka Y.
    • Journal Title

      SCIENTIFIC REPORTS.

      Volume: 10(1) Issue: 1 Pages: 8404-8404

    • DOI

      10.1038/s41598-020-65310-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amide proton transfer imaging of glioblastoma, neuroblastoma, and breast cancer cells on a 11.7?T magnetic resonance imaging system2019

    • Author(s)
      Tanoue Minori、Saito Shigeyoshi、Takahashi Yusuke、Araki Rikita、Hashido Takashi、Kioka Hidetaka、Sakata Yasushi、Yoshioka Yoshichika
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 62 Pages: 181-190

    • DOI

      10.1016/j.mri.2019.07.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 非平面微細加工技術と低侵襲体腔内イメージングデバイス2019

    • Author(s)
      松永忠雄
    • Journal Title

      日本機械学会バイオエンジニアリング部門報

      Volume: 48 Pages: 6-9

    • Related Report
      2019 Annual Research Report
  • [Journal Article] The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.2018

    • Author(s)
      Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.
    • Journal Title

      iScience

      Volume: 6 Pages: 306-318

    • DOI

      10.1016/j.isci.2018.08.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Inflammatory projections after focal brain injury trigger neuronal network disruption: An 18F-DPA714 PET study in mice2018

    • Author(s)
      Hosomi S, Watabe T, Mori Y, Koyama Y, Adachi S, Hoshi N, Ohnishi M, Ogura H, Yoshioka Y, Hatazawa J, Yamashita T, Shimazu T.
    • Journal Title

      NeuroImage: clinical

      Volume: 20 Pages: 946-954

    • DOI

      10.1016/j.nicl.2018.09.031

    • NAID

      120006543327

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 超高磁場MRIと磁性粒子を用いた細胞可視化と細胞トラッキング2018

    • Author(s)
      吉岡芳親, 小林竜馬, 圓見純一郎, 木下学
    • Journal Title

      まぐね= Magnetics Japan

      Volume: 106 Pages: 181-186

    • Related Report
      2018 Annual Research Report
  • [Journal Article] A new manometry device for evaluating the sphincter of Oddi using a fiber-optic pressure sensor2018

    • Author(s)
      Takashi Hanzawa, Tadao Matsunaga, Tomoyuki Koike, Atsushi Kanno, Atsushi Masamune, Katsunori Iijima, Tooru Shimosegawa and Yoichi Haga
    • Journal Title

      Minimally Invasive Therapy & Allied Technologies

      Volume: 27 Pages: 226-232

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高周波用体腔内MRIプローブの設計2021

    • Author(s)
      川端 敏享,李 相錫,松永 忠雄
    • Organizer
      第68回応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 磁気共鳴法で引き出す多様な生体情報:分子・細胞レベルから個体レベルまで2020

    • Author(s)
      吉岡芳親
    • Organizer
      2020年度電気学会マグネティックス マイクロマシン・センサシステム 合同研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 動物用 11.7 T MRI による IVIM パラメータを用いた段階的両側総頚動脈閉塞ラット脳虚血部位の推定2020

    • Author(s)
      藤原俊朗, 森勇樹, 赤松陽介, 吉田研二, 柴田雄二, 増田友行, 小笠原邦明, 吉岡芳親
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 低侵襲医療デバイス作製のための非平面微細加工と実装技術2019

    • Author(s)
      松永忠雄, 李 相錫, 鶴岡典子, 芳賀洋一
    • Organizer
      2019年度精密工学会秋季大会講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Non-planar photofabrication techniques for minimally invasive medical devices2019

    • Author(s)
      Tadao Matsunaga, Noriko Tsuruoka, Sang-Seok Lee, Yoichi Haga
    • Organizer
      The 10th Japan-China-Korea Joint Conference on MEMS/NEMS(JCK MEMS2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intravoxel incoherent motion perfusion magnetic resonance imaging of water molecules in the rat cortex after common carotid artery occlusion at 11.7T.2019

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Ogasawara K, Yoshioka Y
    • Organizer
      Computer Assisted Radiology and Surgery 2019 (CARS2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Detection of ischemic changes in the rat cortex after common carotid artery occulusion using intravoxel incoherent motion diffusion-weighted magnetic resonance imaging at 11.7T.2019

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Yoshida K, Ogasawara K, Yoshioka Y.
    • Organizer
      Brain & Brain PET 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility of using apparent brain temperature map on proton magnetic resonance spectroscopy to detect hemodynamic abnormalities in patients with unilateral chronic major cerebral artery steno-occlusive disease.2019

    • Author(s)
      Namba T, Ogasawara K, Yoshioka Y, Sasaki M, Uwano I, Ishigaki D, Kobayashi M, Yoshida K, Fujiwara S, Terasaki K.
    • Organizer
      The 10th Annual Scientific Symposium of Ultrahigh Field Magnetic Resonance. Max Delbrück Communications Center (MDC.C)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assessment of cerebral ischemic changes in rats using different diffusion-weighted signal models for intravoxel incoherent motion analysis at 11.7T2018

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Yoshida K, Ogasawara K, Yoshioka Y.
    • Organizer
      The 32nd International Congress and Exhibition on Computer Assisted Radiology (CAR)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生殖発生毒性試験における磁気共鳴画像診断(MRI)によるラット胎児の内臓検査能力の向上と課題2018

    • Author(s)
      坂井祐子, 青木嘉信, 藤原道夫, 藤川昭彦, 圓見純一郎, 吉岡芳親.
    • Organizer
      第45回日本毒性学会学術年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] In-vivo Creatine Chemical Exchange Saturation transfer (CrCEST) Imaging in a Mouse Model of Hindlimb Ischemia at 11.7 T-MRI2018

    • Author(s)
      Takahashi Y, Saito S, Kioka H, Takashima S, Sakata Y, Yoshioka Y.
    • Organizer
      第3回 国際磁気共鳴医学会日本支部学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prediction of outcome in bilateral common carotid artery occlusion rats by intravoxel incoherent motion analysis at 11.7 Tesla.2018

    • Author(s)
      Fujiwara S, Mori Y, de la Mora DM, Ogasawara K, Yoshioka Y.
    • Organizer
      European Stroke Conference 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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