Noninvasive biomedical imaging using optical-comb microscopy
| Project/Area Number |
18H01901
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 30020:Optical engineering and photon science-related
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MINAMIKAWA Takeo 徳島大学, ポストLEDフォトニクス研究所, 准教授 (10637193)
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| Co-Investigator(Kenkyū-buntansha) |
浅原 彰文 電気通信大学, 大学院情報理工学研究科, 助教 (00770091)
安井 武史 徳島大学, ポストLEDフォトニクス研究所, 教授 (70314408)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 光コム / 光学顕微鏡 / バイオイメージング / 光学定数イメージング / 生体イメージング / 光学定数 / イメージング |
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| Outline of Final Research Achievements |
In this study, we developed a novel optical microscope, namely "optical frequency comb microscope", which utilizes the optical frequency comb. The optical frequency comb is an extreme light source and involves simultaneous measurement capability of the light intensity and phase because of its ultra-long coherence. We have realized three-dimensional optical constant distribution imaging with submicrometer resolution, which was challenging to achieve so far. We also applied the optical frequency comb microscope to biological imaging, clarifying the possibility of a novel non-invasive biological imaging method based on a three-dimensional optical constant distribution.
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| Academic Significance and Societal Importance of the Research Achievements |
光コムは，これまで超精密分光を中心に活用されてきた．本研究は，光コムの持つ別の視点の特徴（光強度・位相同時計測能）を活用可能性を示した．そのため，本研究は，従来の光コム分光学を学術的に深化させ，あるいは実用的な展開可能性を示した研究である．また，光コムは主に固体物理学を中心とした光物性への応用が主であったが，本研究により生体計測への展開可能性も示すことができ，光物理学から生物学への橋渡し研究としても意義がある．
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Lock-in-detection dual-comb spectroscopy2019
Author(s)
Koresawa Hidenori、Shibuya Kyuki、Minamikawa Takeo、Asahara Akifumi、Oe Ryo、Mizuno Takahiko、Yamagiwa Masatomo、Mizutani Yasuhiro、Iwata Tetsuo、Yamamoto Hirotsugu、Minoshima Kaoru、Yasui Takeshi
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Journal Title
OSA Continuum
Volume: 2
Issue: 6
Pages: 1998-1998
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ultrasonic wave sensing using an optical frequency comb sensing cavity for photoacoustic imaging2019
Author(s)
T. Minamikawa, T. Masuoka, T. Ogura, K. Shibuya, E. Oe, E. Hase, Y. Nakajima, Y. Yamaoka, T. Mizuno, M. Yamagiwa, Y. Mizutani, H. Yamamoto, T. Iwata, K. Minoshima, and T. Yasui
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Journal Title
OSA Continuum
Volume: 2
Issue: 2
Pages: 439-449
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 光コムを用いたスキャンレス共焦点位相イメージング2019
Author(s)
長谷 栄治, 南川 丈夫, 水野 孝彦, 佐藤 克也, 中嶋 善晶, 浅原 彰文, 美濃島 薫, 水谷 康弘, 岩田 哲郎, 山本 裕紹, 安井 武史
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Journal Title
光学
Volume: 48
Pages: 227-227
Related Report
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[Journal Article] Scan-less confocal phase imaging based on dual-comb microscopy2018
Author(s)
Eiji Hase, Takeo Minamikawa, Takahiko Mizuno, Shuji Miyamoto, Ryuji Ichikawa, Yi-Da Hsieh, Kyuki Shibuya, Katsuya Sato, Yoshiaki Nakajima, Akifumi Asahara, Kaoru Minoshima, Yasuhiro Mizutani, Tetsuo Iwata, Hirotsugu Yamamoto, and Takeshi Yasui
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Journal Title
Optica
Volume: 5
Issue: 5
Pages: 634-643
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Optical-frequency-comb microscopy with laser-scanning configuration for simultaneous and spectroscopic amplitude, quantitative phase and polarization imaging2020
Author(s)
Takeo Minamikawa, Shota Nakano, Eiji Hase, Akifumi Asahara, Hidenori Koresawa, Takahiko Mizuno, Hirotsugu Yamamoto, Kaoru Minoshima, and Takeshi Yasui
Organizer
SPIE Photonics West, OPTO 2020
Related Report
Int'l Joint Research
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[Presentation] レーザー走査型光コム定量位相差顕微鏡によるバイオイメージング2019
Author(s)
中野 祥汰, 南川 丈夫, 長谷 栄治, 浅原 彰文, 水野 孝彦, 佐藤 克也, 山口 堅三, 髙成 広起, 鈴木 昭浩, 山本 裕紹, 美濃島 薫, 安井 武史
Organizer
生体医工学シンポジウム2019
Related Report
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