| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
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| Outline of Final Research Achievements |
To elucidate hydration effects on the ion selectivity of ion channels at molecular level, structural changes of metal ion complexes of a partial peptide which constitutes selectivity filter of the ion channel by hydration were investigated by using infrared spectroscopy measured under ultra cold isolated condition. So far, hydration effects upon the ion selectivity have been argued from the point of view of simple thermo dynamics; which is more stable, binding with the selectivity filter or hydration. In this work, however, it was revealed that the hydration effect affects the ion selectivity more directly and plays a crucial role for it in some case.
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