| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Outline of Final Research Achievements |
Organocatalysts are ideal catalysts that are free from toxic heavy metal residues and can address the issues of rising rare metal prices and depletion. In this study, we have developed a variety of conformational analysis methods to elucidate the causes of enantioselectivity of organocatalysts. We used our own ConFinder program to perform fast and accurate conformational analysis. This program allows us to elucidate the specific conformations responsible for the high selectivity, providing hints for the analysis of reaction mechanisms and the design of catalysts. In collaboration with an experimental group developing organocatalysts, we conducted research on asymmetric hydrolysis reactions of esters.
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