| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
A new method for stereoselective construction of a quaternary stereogenic carbon atom was developed based on a formal rearrangement reaction of epoxy cyanoalcohols. The utility of the new method was demonstrated through the concise total synthesis of verrucarol, the saponification product of the macrocyclic fungal metabolite verrucarin J.
On the other hand, total synthesis of Hispidospermidin, a natural product possessing a unique caged skeleton, was accomplished based on a two-step transformation of a ketone into a gem-divinyl compound by a rearrangement reaction.
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