| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
The researcher found a radical NHC catalysis enabling decarboxylative cross-coupling reactions of tertiary/secondary, redox-active esters derived from alkyl carboxylic acids with aldehydes to generate ketones. Additionally, the radical NHC catalysis could be employed with the alkylacylation of acrylonitriles, acylates and styrenes with redox esters obtained from tertiary alkyl carboxylic acids and aldehydes, via a radical relay mechanism.
The researcher achieved reductive umpolung using a copper catalyst and a silylboronate to convert an aldehyde to a nucleophilic α-silyloxyalkylcopper(I) species. The α-silyloxyalkylcopper(I) species, generated via addition of the silylcopper(I) species to an aldehyde followed by [1,2]-Brook rearrangement, could react with various electrophiles to afford a series of alcohol derivatives.
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