| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
The catalysis for hydrogen-atom transfer (HAT) is a powerful tool for the direct conversion of inert C-H bonds to C-C bonds. We have designed a zwitterionic 1,2,3-triazolium amidate as an effective modular hydrogen-atom transfer catalyst for photoredox C－H functionalization. This zwitterionic amidate is stable yet amenable to single-electron oxidation for generating a highly reactive amidyl radical. By the combined use with an appropriate Ir-based visible-light photoredox catalyst, we have accomplished efficient catalytic C-H alkylation of a range of C-H nucleophiles. These results provide the new approach to the design of HAT catalysts, and we believe that the judicious exploitation of the structural modularity of zwitterionic amidates holds vast potential for the development of catalyst-controlled selective C-H functionalization methodologies.
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