| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
In this study, we have developed acid-base hybrid organocatalysts that have both acidic and basic functional groups. A number of organocatalysts with both acidic and basic functional groups including amino acids have been reported. However, when acidic and basic functional groups coexist, they form acid-base complexes to inactivate the catalyst. We have developed novel catalysts by introducing both acidic and basic functional groups into a rigid framework to suppress the formation of intramolecular acid-base complexes. These acid-base hybrid organocatalysts showed sufficient reactivity and were found to be effective for novel asymmetric reactions.
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