| Budget Amount *help |
¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Outline of Final Research Achievements |
In this project, to establish the synthetic way to structurally complex natural products possessing multi-cyclic system, total syntheses of taxol and neotuberostemonine were investigated. On the synthetic study of taxol, total synthesis was achieved utilizing the Sm-mediated construction of eight-membered ring and the introduction of bridge-head olefin by the double Rubottom oxidation as the key transformation. On the other hand, the total synthesis of neotuberostemonine was also accomplished. The sequential sigmatropic rearrangements, Sm-mediated cyclization and lactam-selective nucleophilic addition were employed for the synthesis. These achievements established the stereoselective chiral synthesis of structurally complex multi-cyclic natural products.
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