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Selective Recognition of Biomolecules by Polyaromatic Nanopockets

Research Project

Project/Area Number 18H01990
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 34010:Inorganic/coordination chemistry-related
Research InstitutionTokyo Institute of Technology

Principal Investigator

Yoshizawa Michito  東京工業大学, 科学技術創成研究院, 教授 (70372399)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords生体分子 / センシング / 分子カプセル / 生体関連分子 / 超分子化学
Outline of Final Research Achievements

For the development of selective sensing systems for various biomolecules in water, we designed and prepared polyaromatic nanopockets inspired by biological protein nanopockets. Using the synthetic nanopocket, we succeeded in the selective binding of male hormones such as testosterone from a mixture of male and female hormones in water. In addition, selective recognition of fatty acids with multiple unsaturated units was also achieved by the nanopocket.

Academic Significance and Societal Importance of the Research Achievements

ナノ空間の化学は、新規な分析・分離材料や高性能な反応・触媒の開発の観点から、国内外で勢力的に研究されている。しかしながら、その大部分は有機溶媒中での研究で、また、その対象は金属イオン・ガス分子・合成化合物などに限定されていた。本研究では、生体と同じ水を溶媒として、重要な生体分子を対象とし、独自の芳香環ナノポケットを活用することで、簡便で高選択的なセンシングシステムを開発した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (41 results)

All 2021 2020 2019 2018 Other

All Journal Article (25 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 25 results,  Open Access: 7 results) Presentation (12 results) (of which Int'l Joint Research: 7 results,  Invited: 12 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Three Host Peculiarities of a Cycloalkane-Based Micelle Toward Large Metal-Complex Guests2020

    • Author(s)
      M. Hanafusa, Y. Tsuchida, K. Matsumoto, K. Kondo, M. Yoshizawa
    • Journal Title

      Nature Commun.

      Volume: 11 Issue: 1 Pages: 6061-6061

    • DOI

      10.1038/s41467-020-19886-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transition Metal-Free Supramolecular Photoredox Catalysis in Water: A Phenoxazine Photocatalyst Encapsulated in V-Shaped Aromatic Amphiphiles2020

    • Author(s)
      N. Noto, Y. Hyodo, M. Yoshizawa, T. Koike, M. Akita
    • Journal Title

      ACS Catal.

      Volume: 10 Issue: 23 Pages: 14283-14289

    • DOI

      10.1021/acscatal.0c04221

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Cellular Uptake of Platinum by a Tetracationic Pt(II) Nanocapsule and its Implications to Cancer Treatment2020

    • Author(s)
      A. Ahmedova, R. Mihaylova, S. Stoykova, V. Mihaylova, T. Paunova-Krasteva, L. Mihaylov, S. Stoitsova, D. Nihtianova, G. Momekov, D. Momekova, M. Yoshizawa
    • Journal Title

      Eur. J. Pharm. Sci.

      Volume: 155 Pages: 105545-105545

    • DOI

      10.1016/j.ejps.2020.105545

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An Atropisomeric M2L4 Cage Mixture Displaying Guest-Induced Convergence and Strong Guest Emission in Water2020

    • Author(s)
      T. Tsutsui, L. Catti, K. Yoza, M. Yoshizawa
    • Journal Title

      Chem. Sci.

      Volume: 11 Issue: 31 Pages: 8145-8150

    • DOI

      10.1039/d0sc03223a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Aromatic Micelle with Bent Pentacene-based Panels: Encapsulation of Perylene Bisimide Dyes and Graphene Nanosheets2020

    • Author(s)
      K. Ito, T. Nishioka, M. Akita, A. Kuzume, K. Yamamoto, M. Yoshizawa
    • Journal Title

      Chem. Sci.

      Volume: 11 Issue: 26 Pages: 6752-6757

    • DOI

      10.1039/d0sc01748e

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anisotropic Contraction of a Polyaromatic Capsule and Its Cavity-Induced Compression Effect2020

    • Author(s)
      Kishida Natsuki、Matsumoto Kyosuke、Tanaka Yuya、Akita Munetaka、Sakurai Hidehiro、Yoshizawa Michito
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 21 Pages: 9599-9603

    • DOI

      10.1021/jacs.0c02932

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N‐Doping of Polyaromatic Capsules: Small Cavity Modification Leads to Large Change in Host?Guest Interactions2020

    • Author(s)
      Dobashi Hiroki、Catti Lorenzo、Tanaka Yuya、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 29 Pages: 11881-11885

    • DOI

      10.1002/anie.202004168

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a Black Dye with Absorption Capabilities Across the Visible-to-Near-Infrared Region: A MO-Mixing Approach via Heterometal Coordination of Expanded Porphyrinoid2020

    • Author(s)
      Wang Yue、Kai Hiroto、Ishida Masatoshi、Gokulnath Sabapathi、Mori Shigeki、Murayama Tomotaka、Muranaka Atsuya、Uchiyama Masanobu、Yasutake Yuhsuke、Fukatsu Susumu、Notsuka Yusuke、Yamaoka Yoshihisa、Hanafusa Mamiko、Yoshizawa Michito、Kim Gakhyun、Kim Dongho、Furuta Hiroyuki
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 14 Pages: 6807-6813

    • DOI

      10.1021/jacs.0c01824

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Recognition and Stabilization of Unsaturated Fatty Acids by a Polyaromatic Receptor2020

    • Author(s)
      K. Niki, T. Tsutsui, M. Yamashina, M. Akita, M. Yoshizawa
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 59 Issue: 26 Pages: 10489-10492

    • DOI

      10.1002/anie.202003253

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bent Anthracene Dimers as Versatile Building Blocks for Supramolecular Capsules2019

    • Author(s)
      Yoshizawa Michito、Catti Lorenzo
    • Journal Title

      Accounts of Chemical Research

      Volume: 52 Issue: 8 Pages: 2392-2404

    • DOI

      10.1021/acs.accounts.9b00301

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Redox-Active Heterocyclic Capsule: Radical Generation, Oxygenation, and Guest Uptake/Release2019

    • Author(s)
      Satoh Yoshiyuki、Catti Lorenzo、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Journal of the American Chemical Society

      Volume: 141 Issue: 31 Pages: 12268-12273

    • DOI

      10.1021/jacs.9b03419

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Peanut-Shaped Polyaromatic Capsule: Solvent-Dependent Transformation and Electronic Properties of a Non-Contacted Fullerene Dimer2019

    • Author(s)
      K. Matsumoto, S. Kusaba, Y. Tanaka, Y. Sei, M. Akita, K. Aritani, M. Haga, M. Yoshizawa
    • Journal Title

      Angew. Chem. Int. Ed.,

      Volume: 58 Issue: 25 Pages: 8463-8467

    • DOI

      10.1002/anie.201903117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polyaromatic nanocapsules as photoresponsive hosts in water2019

    • Author(s)
      Catti Lorenzo、Kishida Natsuki、Kai Tomokuni、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1948-1948

    • DOI

      10.1038/s41467-019-09928-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Polyaromatic Gemini Amphiphile That Assembles into a Well‐Defined Aromatic Micelle with Higher Stability and Host Functions2019

    • Author(s)
      Nishioka Tomoya、Kuroda Kiyonori、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 58 Issue: 20 Pages: 6579-6583

    • DOI

      10.1002/anie.201814624

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A polyaromatic receptor with high androgen affinity2019

    • Author(s)
      Yamashina Masahiro、Tsutsui Takahiro、Sei Yoshihisa、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Science Advances

      Volume: 5 Issue: 4 Pages: 3179-3179

    • DOI

      10.1126/sciadv.aav3179

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Open versus Closed Polyaromatic Nanocavity: Enhanced Host Abilities toward Large Dyes and Pigments2019

    • Author(s)
      Tsutsui Takahiro、Kusaba Shunsuke、Yamashina Masahiro、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 17 Pages: 4320-4324

    • DOI

      10.1002/chem.201806409

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Pentacene-based Nanotube Displaying Enriched Electrochemical and Photochemical Activities2018

    • Author(s)
      Kuroda Kiyonori、Yazaki Kohei、Tanaka Yuya、Akita Munetaka、Sakai Hayato、Hasobe Taku、Tkachenko Nikolai V.、Yoshizawa Michito
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 58 Issue: 4 Pages: 1115-1119

    • DOI

      10.1002/anie.201812976

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Supramolecular Approach to the Preparation of Nanographene Adlayers Using Water-Soluble Molecular Capsules2018

    • Author(s)
      Origuchi Sakura、Kishimoto Mai、Yoshizawa Michito、Yoshimoto Soichiro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 47 Pages: 15481-15485

    • DOI

      10.1002/anie.201809258

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cramming versus threading of long amphiphilic oligomers into a polyaromatic capsule2018

    • Author(s)
      Yamashina Masahiro、Kusaba Shunsuke、Akita Munetaka、Kikuchi Takashi、Yoshizawa Michito
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 4227-4227

    • DOI

      10.1038/s41467-018-06458-w

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Supercooling of functional alkyl-π molecular liquids2018

    • Author(s)
      Lu Fengniu、Jang Keumhee、Osica Izabela、Hagiwara Keita、Yoshizawa Michito、Ishii Masashi、Chino Yoshiaki、Ohta Kazuchika、Ludwichowska Kinga、Kurzydlowski Krzysztof Jan、Ishihara Shinsuke、Nakanishi Takashi
    • Journal Title

      Chemical Science

      Volume: 9 Issue: 33 Pages: 6774-6778

    • DOI

      10.1039/c8sc02723d

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polyaromatic molecular tubes: from strategic synthesis to host functions2018

    • Author(s)
      Yazaki Kohei、Catti Lorenzo、Yoshizawa Michito
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 26 Pages: 3195-3206

    • DOI

      10.1039/c8cc00799c

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrophilic Oligo(lactic acid)s Captured by a Hydrophobic Polyaromatic Cavity in Water2018

    • Author(s)
      Kusaba Shunsuke、Yamashina Masahiro、Akita Munetaka、Kikuchi Takashi、Yoshizawa Michito
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 14 Pages: 3706-3710

    • DOI

      10.1002/anie.201800432

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alkylation-, Heating-, and Doping-Induced Emission Enhancement of a Polyaromatic Tube in the Solid State2018

    • Author(s)
      Kuroda Kiyonori、Otsuki Masafumi、Yazaki Kohei、Sei Yoshihisa、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 13 Issue: 5 Pages: 515-519

    • DOI

      10.1002/asia.201800034

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Encapsulation-induced emission enhancement (EIEE) of Eu(iii)-complexes by aromatic micelles in water2018

    • Author(s)
      Kai Tomokuni、Kishimoto Mai、Akita Munetaka、Yoshizawa Michito
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 8 Pages: 956-959

    • DOI

      10.1039/c7cc09450g

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-Assembly Process of a Pd2L4 Capsule: Steric Interactions between Neighboring Components Favor the Formation of Large Intermediates2018

    • Author(s)
      Kai Shumpei、Nakagawa Masanori、Kojima Tatsuo、Li Xin、Yamashina Masahiro、Yoshizawa Michito、Hiraoka Shuichi
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Issue: 16 Pages: 3965-3969

    • DOI

      10.1002/chem.201705253

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 「芳香環ナノ空間の機能:生体分子の見分け方」2020

    • Author(s)
      角田瑠輝・◯吉沢道人
    • Organizer
      日本化学会 第101回 春季年会(オンライン)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Polyaromatic Nanocapsules: from Rational Design to Host Functions2019

    • Author(s)
      M. Yoshizawa
    • Organizer
      Department Seminar, Indian Institute of Technology (IIT), Madras
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Polyaromatic Nanocapsules: from Rational Design to Host Functions2019

    • Author(s)
      M. Yoshizawa
    • Organizer
      Department Seminar, Indian Institute of Scienece (IISc)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Polyaromatic Nanocapsules: Selective Recognition of Biomolecules2019

    • Author(s)
      M. Yoshizawa
    • Organizer
      Modern Trends In Inorganic Chemistry-XVIII (MTICXVIII)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Host Functions of Polyaromatic Coordination Capsules in Water2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      The 2nd International Symposium on Coordination Asymmetry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polyaromatic Nanocapsules with Unique Host Functions2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      4th International Symposium on Center of Excellence for Innovative Material Sciences Based on Supramolecules
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unusual Phenomena within Polyaromatic Molecular Capsules2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      43rd International Conference on Coordination Chemistry (ICCC 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子カプセルの精密設計と機能開拓 -新しい重合開始剤や水溶化剤の開発など-2018

    • Author(s)
      吉沢道人
    • Organizer
      技術情報協会 セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Unusual Host Functions of Polyaromatic Coordination Capsules2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      he Third Japan-UK Joint Symposium on Coordination Chemistry
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polyaromatic Nanocapsules: from Strategic Synthesis to Host Functions2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      Department Seminar, University of Cambridge
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unique Host Properties of Polyaromatic Coordination Capsules2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      The 255th ACS National Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Polyaromatic Nanocapsules: from Strategic Synthesis to Host Functions2018

    • Author(s)
      M. Yoshizawa
    • Organizer
      Dep. of Chem. and Biochem., UC San Diego, Special Seminar
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Remarks] 吉沢研究室ホームページ

    • URL

      http://www.res.titech.ac.jp/~smart/nspace.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 吉沢研究室

    • URL

      http://www.res.titech.ac.jp/~smart/nspace.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 穐田・吉沢研究室ホームページ

    • URL

      http://www.res.titech.ac.jp/~smart/smartj.html

    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 揮発性有機化合物の吸着方法2021

    • Inventor(s)
      角田瑠輝・吉沢道人
    • Industrial Property Rights Holder
      角田瑠輝・吉沢道人
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-011658
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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