Selective Recognition of Biomolecules by Polyaromatic Nanopockets
Project/Area Number |
18H01990
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
|
Keywords | 生体分子 / センシング / 分子カプセル / 生体関連分子 / 超分子化学 |
Outline of Final Research Achievements |
For the development of selective sensing systems for various biomolecules in water, we designed and prepared polyaromatic nanopockets inspired by biological protein nanopockets. Using the synthetic nanopocket, we succeeded in the selective binding of male hormones such as testosterone from a mixture of male and female hormones in water. In addition, selective recognition of fatty acids with multiple unsaturated units was also achieved by the nanopocket.
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Academic Significance and Societal Importance of the Research Achievements |
ナノ空間の化学は、新規な分析・分離材料や高性能な反応・触媒の開発の観点から、国内外で勢力的に研究されている。しかしながら、その大部分は有機溶媒中での研究で、また、その対象は金属イオン・ガス分子・合成化合物などに限定されていた。本研究では、生体と同じ水を溶媒として、重要な生体分子を対象とし、独自の芳香環ナノポケットを活用することで、簡便で高選択的なセンシングシステムを開発した。
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Enhanced Cellular Uptake of Platinum by a Tetracationic Pt(II) Nanocapsule and its Implications to Cancer Treatment2020
Author(s)
A. Ahmedova, R. Mihaylova, S. Stoykova, V. Mihaylova, T. Paunova-Krasteva, L. Mihaylov, S. Stoitsova, D. Nihtianova, G. Momekov, D. Momekova, M. Yoshizawa
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Journal Title
Eur. J. Pharm. Sci.
Volume: 155
Pages: 105545-105545
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Supercooling of functional alkyl-π molecular liquids2018
Author(s)
Lu Fengniu、Jang Keumhee、Osica Izabela、Hagiwara Keita、Yoshizawa Michito、Ishii Masashi、Chino Yoshiaki、Ohta Kazuchika、Ludwichowska Kinga、Kurzydlowski Krzysztof Jan、Ishihara Shinsuke、Nakanishi Takashi
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Journal Title
Chemical Science
Volume: 9
Issue: 33
Pages: 6774-6778
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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