Microfluidic thread-based sensor for the detection of therapeutic antibodies in blood at point-of-care
| Project/Area Number |
18H02008
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | Keio University |
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Principal Investigator |
CITTERIO Daniel 慶應義塾大学, 理工学部(矢上), 教授 (00458952)
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| Co-Investigator(Kenkyū-buntansha) |
蛭田 勇樹 慶應義塾大学, 理工学部(矢上), 講師 (60710944)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 抗体医薬品 / POCT / 糸基板センサー / 生物発光 / マイクロ流体 |
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| Outline of Final Research Achievements |
Regular monitoring of blood drug levels at point-of-care (POC) would allow personalized drug dosage without involving centralized laboratories or the need for daily hospital visits. In this research, as a new analytical method to quantify therapeutic antibodies at POC, we developed fully integrated, rapid, low-cost, disposable and simple-to-use microfluidic thread-based analytical devices (μTADs) for bioluminescence-based antibody detection from a single drop of blood with a digital camera or a smartphone.
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| Academic Significance and Societal Importance of the Research Achievements |
薬物を投与する際には、期待する効果と副作用が現れるが、患者ごとに薬物動態が異なり、限られた有効血中濃度範囲に管理することが重要である。そのために、治療薬物モニタリングが行われており、患者は普通、通院しなくてはならない。本研究で開発した抗体医薬品の分析技術は、微量の血液サンプルで複雑な操作、高価な装置を必要とせず血中濃度をモニタリングできるため、Point of Care (POC)での定期的な血中治療薬物濃度モニタリングへの応用が期待できる。
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Report
(4 results)
Research Products
(26 results)
