| Budget Amount *help |
¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
In this study, various molecular transformation reactions using perfluorinated compounds, which are industrially viable bulk materials, as starting materials have been developed. This research proposes a novel synthetic approach for useful fluorine-containing organic compounds. By employing aromatic nucleophilic substitution reactions of polyfluoroarenes, carbon-fluorine bond functionalization reactions of tetrafluoroethylene, and arylation reactions of fluorocarboxylic acids, a wide range of fluorine-containing organic compounds have been successfully synthesized. Furthermore, we have demonstrated the utility of these reactions in the synthesis of functional organic molecules and bioactive compounds.
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