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Higher-Order Structure Formed by Flower Micelles of Amphiphilic Random and Alternating Copolymers

Research Project

Project/Area Number 18H02020
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 35010:Polymer chemistry-related
Research InstitutionOsaka University

Principal Investigator

Sato Takahiro  大阪大学, 理学研究科, 教授 (10196248)

Co-Investigator(Kenkyū-buntansha) 寺尾 憲  大阪大学, 理学研究科, 准教授 (60334132)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywords両親媒性高分子 / ランダム共重合体 / 交互共重合体 / 花型ミセル / フラワーネックレス / 光散乱 / 小角X線散乱 / 蛍光寿命測定 / 高分子ミセル / 花形ミセル / 疎水化多糖
Outline of Final Research Achievements

Amphiphilic random copolymers form different self-assemblies (random aggregate, flower micelle, and flower necklace) in an aqueous solution by association of hydrophobic groups attached to the copolymer chain. Structural parameters of the self-assemblies were related to the main chain structure, the chemical structure of hydrophilic groups, degree of polymerization, and the hydrophobic content. These achievements make molecular design possible, which can control the self-assembly structure of amphiphilic random copolymers.
In addition, the flower micelle formed by the amphiphilic alternating copolymer, which can be regarded as a model of the amphiphilic random copolymer, have the uniform sizes of the hydrophobic core and the loop chain, even if they have molecular weight and composition distributions. This uniformity in size enables the flower micelle to form higher-order arrangements in concentrated solutions, just like the colloidal crystal formed by spherical particle systems.

Academic Significance and Societal Importance of the Research Achievements

両親媒性ランダム共重合体が水溶液中で形成する高分子ミセルは、ドラッグデリバリーシステムへの応用が近年注目されているが、高濃度で形成される高次の秩序構造は、フォトニック結晶、リソグラフィー、選択的透過膜、イオン伝導膜などへの応用も期待される。当該研究の成果は、両親媒性ランダム共重合体のそのような応用する際に必要となる、高分子ミセル構造とその高次構造を制御する技術の基盤となる。また、タンパク質構造予想は今後のバイオテクノロジー技術の根幹となるが、両親媒性ランダム共重合体とタンパク質との構造類似性により、両親媒性ランダム共重合体が形成する高分子ミセル構造の理解は、タンパク質構造予想にも寄与する。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (37 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (21 results) (of which Int'l Joint Research: 1 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] Shenyang Univ. of Chem. Tech.(中国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Korea University(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Helsinki(フィンランド)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Micellar structure of hydrophobically modified polysaccharides in aqueous solution2022

    • Author(s)
      Takahiro Sato, Jia Yang, Ken Terao
    • Journal Title

      Polymer Journal

      Volume: 54 Issue: 4 Pages: 403-412

    • DOI

      10.1038/s41428-021-00561-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transition from the Random Coil to the Flower Necklace of a Hydrophobically Modified Pullulan in Aqueous Solution by Changing the Degree of Substitution2021

    • Author(s)
      Jia Yang, Takahiro Sato
    • Journal Title

      Polymer

      Volume: 214 Pages: 123346-123346

    • DOI

      10.1016/j.polymer.2020.123346

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the Micelle Formed by a Hydrophobically Modified Pullulan in Aqueous Solution: Size Exclusion Chromatography2021

    • Author(s)
      Jia Yang, Takahiro Sato
    • Journal Title

      Polymers

      Volume: 13 Issue: 8 Pages: 1237-1237

    • DOI

      10.3390/polym13081237

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Conformation of Pullulan in Aqueous Solution Studied by Small-Angle X-Ray Scattering2020

    • Author(s)
      Jia Yang, Takahiro Sato
    • Journal Title

      Polymers

      Volume: 12 Issue: 6 Pages: 1266-1266

    • DOI

      10.3390/polym12061266

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple Association-Dissociation Equilibria in Solutions of Amphiphilic Molecules2020

    • Author(s)
      Yan Li, Takahiro Sato
    • Journal Title

      Langmuir

      Volume: 36 Issue: 29 Pages: 8323-8343

    • DOI

      10.1021/acs.langmuir.0c01067

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Micellar Structure of a Hydrophobically Modified Pullulan in an Aqueous Solution2020

    • Author(s)
      Jia Yang, Takahiro Sato
    • Journal Title

      Macromolecules

      Volume: 53 Issue: 18 Pages: 7970-7979

    • DOI

      10.1021/acs.macromol.0c01319

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of Block Copolymer Micelles Formed in Solution2019

    • Author(s)
      SATO Takahiro、TAKAHASHI Rintaro
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 76 Issue: 1 Pages: 3-22

    • DOI

      10.1295/koron.2018-0052

    • NAID

      130007556836

    • ISSN
      0386-2186, 1881-5685
    • Year and Date
      2019-01-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dehydration, Micellization, and Phase Separation of Thermosensitive Polyoxazoline Star Block Copolymers in Aqueous Solution2019

    • Author(s)
      Sezonenko Tetiana、Qiu Xing-Ping、Winnik Fran?oise M.、Sato Takahiro
    • Journal Title

      Macromolecules

      Volume: 52 Issue: 3 Pages: 935-944

    • DOI

      10.1021/acs.macromol.8b02528

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self-Assembly of Amphiphilic Amylose Derivatives in Aqueous Media2019

    • Author(s)
      Kameyama Yuki、Kitamura Shinichi、Sato Takahiro、Terao Ken
    • Journal Title

      Langmuir

      Volume: 35 Issue: 20 Pages: 6719-6726

    • DOI

      10.1021/acs.langmuir.9b00985

    • NAID

      120007053196

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micellization and Phase Separation in Aqueous Solutions of Thermosensitive Block Copolymer Poly(N-isopropylacrylamide)-b-poly(N-vinyl-2-pyrrolidone) upon Heating2019

    • Author(s)
      C. Kuang, S. Yusa, T. Sato
    • Journal Title

      Macromolecules

      Volume: 52 Issue: 13 Pages: 4812-4819

    • DOI

      10.1021/acs.macromol.9b00807

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Studies of Polymer Nano-Assemblies in Solution by Scattering Techniques2018

    • Author(s)
      SATO Takahiro、LI Yan
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 75 Issue: 4 Pages: 293-336

    • DOI

      10.1295/koron.2018-0003

    • NAID

      130007419164

    • ISSN
      0386-2186, 1881-5685
    • Year and Date
      2018-07-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] オクテニルコハクコはく酸無水物により疎水化されたプルランの水溶液中でのミセル形成2020

    • Author(s)
      Jia Yang, Takahiro Sato
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] フラワーネックレスミセルを形成する両親媒性交互共重合体の濃厚水溶液2020

    • Author(s)
      竹内佐保美、佐藤尚弘
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 水溶液中における両親媒性交互共重合体と球状タンパク質との複合体形成2020

    • Author(s)
      植野悠一, 佐藤尚弘
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ポリ(N-イソプロピルアクリルアミド)の相分離水溶液中におけるコロイドの分散状態2020

    • Author(s)
      韓 佳運, 佐藤 尚弘
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 両親媒性交互共重合体の水溶液中におけるミセル構造のpH依存性2020

    • Author(s)
      江上侑希, 佐藤尚弘
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] カチオン性界面活性剤で安定化されたエマルションの分散状態2020

    • Author(s)
      柳下 薫、佐藤尚弘
    • Organizer
      第66回高分子研究発表会(神戸)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 両親媒性交互共重合体の水溶液中におけるミセル構造のpH依存性2020

    • Author(s)
      江上侑希, 佐藤尚弘
    • Organizer
      第69回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Micellar Structure of a Hydrophobically Modified Pullulan in Aqueous Solution2020

    • Author(s)
      Jia Yang, Takahiro Sato
    • Organizer
      第69回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 感熱応答性高分子の水溶液中で起こる相分離現象2020

    • Author(s)
      韓 佳運, 佐藤 尚弘
    • Organizer
      第69回高分子討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 油中油乳液のブロック共重合体による乳化安定化2020

    • Author(s)
      浅野 到、齋藤 弘樹、佐藤 尚弘
    • Organizer
      第29回ポリマー材料フォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 感熱応答性ポリオキサゾリン星型ブロック共重合体の水溶液中での脱水和・ミセル化・相分離2019

    • Author(s)
      Tetiana Sezonenko, Xing-Ping Qiu, Francoise M. Winnik, 佐藤尚弘
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ポリ(N-イソプロピルアクリルアミド)の相分離水溶液中におけるコロイドの分散状態2019

    • Author(s)
      韓 佳運, 佐藤 尚弘, 高橋 倫太郎
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effect of Addition of PNIPAM homopolymer on the Phase Separation and Micellization in Aqueous Solutions of PNIPAM-b-Poly(N-vinyl-2-pyrrolidone) upon Heating2019

    • Author(s)
      Chen Kuang, Takahiro Sato, Shin-ichi Yusa
    • Organizer
      第68回高分子学会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 両親媒性交互共重合体の水溶液中におけるミセル構造のpH依存性2019

    • Author(s)
      江上侑希, 佐藤尚弘
    • Organizer
      第65回高分子研究発表会(神戸)
    • Related Report
      2018 Annual Research Report
  • [Presentation] カチオン性界面活性剤により安定化された乳液の分散状態2019

    • Author(s)
      萩原真衣, 佐藤尚弘
    • Organizer
      第65回高分子研究発表会(神戸)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 球状タンパク質とアニオン性界面活性剤の水溶液中における相互作用の温度依存性2019

    • Author(s)
      瀧口俊樹, 佐藤尚弘
    • Organizer
      第65回高分子研究発表会(神戸)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大豆油とレシチンと水からなる乳液中におけるコロイド分散状態2019

    • Author(s)
      山田 兼三, 佐藤 尚弘
    • Organizer
      第68回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 両親媒性ランダム・周期共重合体が溶液中で形成する花形ミセル2019

    • Author(s)
      佐藤 尚弘
    • Organizer
      第68回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Conformation and Self-Association Behavior of Hydrophobically Modified Pullulan by Octenyl Succinic Anhydride in Aqueous Media2019

    • Author(s)
      Jia Yang, Takahiro Sato
    • Organizer
      第68回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ポリマーソームの形成過程の動力学2019

    • Author(s)
      高橋 倫太郎, Narayanan Theyencheri, 遊佐 真一, 佐藤 尚弘
    • Organizer
      第68回高分子討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Conformation and Self-Association Behavior of Hydrophobically Modified Pullulan by Octenyl Succinic Anhydride in Aqueous Media2019

    • Author(s)
      Jia Yang, Takahiro Sato
    • Organizer
      2nd GLowing Polymer Symposium in KANTO
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] 基礎高分子科学 第2版2020

    • Author(s)
      高分子学会
    • Total Pages
      496
    • Publisher
      東京化学同人
    • ISBN
      9784807909629
    • Related Report
      2018 Annual Research Report
  • [Remarks] 佐藤研究室|大阪大学大学院理学研究科高分子科学専攻

    • URL

      http://www.chem.sci.osaka-u.ac.jp/lab/sato/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report 2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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