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Regulation of dynamic aggregation states of polymer/water interfaces and their application to bioinert materilas

Research Project

Project/Area Number 18H02037
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 35020:Polymer materials-related
Research InstitutionKyushu University

Principal Investigator

Matsuno Hisao  九州大学, 工学研究院, 准教授 (50376696)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords界面 / 分子鎖凝集状態 / 水 / 動的構造 / バイオイナート
Outline of Final Research Achievements

For the purpose of understanding and controlling the aggregation states and thermal molecular motion in the outermost region of the polymer film, various polymers were synthesized based on precision polymerization and thin films of them were prepared. Surface and interface were characterized by various microscopy and spectroscopy techniques. As a result, it was found that the thicker and more diffused layer at the outermost interface expressed the higher bio-inert property. In addition, it was clarified that the degree of these factors could be easily tuned by using silica nano particles, and that the adhesion and extension behaviors of fibroblasts could be arbitrarily controlled.

Academic Significance and Societal Importance of the Research Achievements

生体不活性を示す高分子材料は、医療デバイスや建築資材の表面材料、コーティング剤として極めて重要である。本研究の実施により、より高い生体不活性、また、安定にその作用を発現するための材料作製の設計指針を提案した。これらの成果は、より安全安心な医療デバイスや公共施設の提供に繋がり、社会全体のQOL向上役立つことが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (31 results)

All 2021 2020 2019 2018

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (19 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Poly[oligo(2-ethyl-2-oxazoline) methacrylate] as a surface modifier for bioinertness2021

    • Author(s)
      Hong Jin-Hyeok、Totani Masayasu、Kawaguchi Daisuke、Yamada Norifumi L.、Matsuno Hisao、Tanaka Keiji
    • Journal Title

      Polymer Journal

      Volume: 53 Issue: 5 Pages: 643-653

    • DOI

      10.1038/s41428-020-00459-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Facile Surface Functionalization Method for Polymers Using a Nonsolvent2020

    • Author(s)
      Hirata, T; Taneda, H; Nishio, K; Inutsuka, M; Yamada, NL; Nemoto, F; Minagawa, Y; Matsuno, H; Tanaka, K
    • Journal Title

      ACS Applied Bio Materials

      Volume: 3 Issue: 4 Pages: 2170-2176

    • DOI

      10.1021/acsabm.0c00028

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mesoscopic heterogeneity in a nanocellulose-containing cell storage medium2020

    • Author(s)
      Shundo Atsuomi、Matsumoto Yuji、Hayashi Hisato、Tsuruzoe Nobutomo、Matsuno Hisao、Tanaka Keiji
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 8 Issue: 21 Pages: 4570-4574

    • DOI

      10.1039/d0tb00219d

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of a Bioinert Interface Using an Amphiphilic Block Copolymer Containing a Bottlebrush Unit of Oligo(oxazoline)2020

    • Author(s)
      Hong Jin-Hyeok、Totani Masayasu、Kawaguchi Daisuke、Masunaga Hiroyasu、Yamada Norifumi L.、Matsuno Hisao、Tanaka Keiji
    • Journal Title

      ACS Applied Bio Materials

      Volume: 3 Issue: 11 Pages: 7363-7368

    • DOI

      10.1021/acsabm.0c01118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Dynamic Interface Based on Segregation of an Amphiphilic Hyperbranched Polymer Containing Fluoroalkyl and Oligo(ethylene oxide) Moieties2020

    • Author(s)
      Yukari Oda, Manabu Inutsuka, Ryo Awane, Masayasu Totani, Norifumi L. Yamada, Masayuki Haraguchi, Masaaki Ozawa, Hisao Matsuno, and Keiji Tanaka
    • Journal Title

      Macromolecules

      Volume: 53 Issue: 7 Pages: 2380-2387

    • DOI

      10.1021/acs.macromol.9b02064

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggregation State and Thermal Molecular Motion of a Bio-Inert Polymer at the Water Interface2019

    • Author(s)
      Hisao Matsuno, Keiji Tanaka
    • Journal Title

      KOBUNSHI RONBUNSHU

      Volume: 76 Issue: 3 Pages: 185-195

    • DOI

      10.1295/koron.2019-0013

    • NAID

      130007652575

    • ISSN
      0386-2186, 1881-5685
    • Year and Date
      2019-05-25
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Water-induced Surface Reorganization of Bioscaffolds Composed of an Amphiphilic Hyperbranched Polymer2019

    • Author(s)
      Hisao Matsuno, Masayasu Totani, Arisa Yamamoto, Masayuki Haraguchi, Masaaki Ozawa, Keiji Tanaka
    • Journal Title

      Polym. J.

      Volume: 51 Issue: 10 Pages: 1045-1053

    • DOI

      10.1038/s41428-019-0212-5

    • NAID

      40022176701

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical Stabilization of Deoxyribonucleic Acid Solid Films Based on Hydrated Ionic Liquid2019

    • Author(s)
      Morimitsu Yuma、Matsuno Hisao、Ohta Noboru、Sekiguchi Hiroshi、Takahara Atsushi、Tanaka Keiji
    • Journal Title

      Biomacromolecules

      Volume: 21 Issue: 2 Pages: 464-471

    • DOI

      10.1021/acs.biomac.9b01207

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of a star-like hyperbranched polymer having hydrophilic arms for anti-biofouling coating2019

    • Author(s)
      Masayasu Totani, Ling Liu, Hisao Matsuno, Keiji Tanaka
    • Journal Title

      Journal of Materials Chemistry B

      Volume: 7 Issue: 7 Pages: 1045-1049

    • DOI

      10.1039/c8tb03104e

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1)Cellular Behaviors on Polymeric Scaffolds with 2D-patterned Mechanical Properties2018

    • Author(s)
      Shinichiro Shimomura, Hisao Matsuno, Yohei Kinoshita, Satoshi Fujimura, Keiji Tanaka
    • Journal Title

      Polymer Journal

      Volume: 50 Issue: 8 Pages: 737-743

    • DOI

      10.1038/s41428-018-0043-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] ポリオキサゾリンを基盤とする生体不活性界面の凝集状態2021

    • Author(s)
      松野寿生, Jinhyeok HONG, 戸谷匡康, 川口大輔, 山田悟史, 田中敬二
    • Organizer
      2020年度量子ビームサイエンスフェスタ
    • Related Report
      2020 Annual Research Report
  • [Presentation] Bioinert Properties of Epoxy/Betaine Based Polymer Adhesive2020

    • Author(s)
      Masayasu Totani, Junko Katayama, Masaaki Ozawa, Nobutomo Tsuruzoe, Hisao Matsuno, Keiji Tanaka
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of Chain Length of Poly(2-oxazoline) Derivatives on Bioinert Properties2020

    • Author(s)
      Jin-Hyeok Hong, Masayasu Totani, Hisao Matsuno, Keiji Tanaka
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Thermal Molecular Motion of Poly(methyl methacrylate) in Nanofiber Mats2020

    • Author(s)
      Hisao Matsuno, Ryo Matsumoto, Masayasu Totani, Keiji Tanaka
    • Organizer
      第69回高分子学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 電界紡糸ポリメタクリル酸メチルナノファイバーマットにおける分子鎖熱運動性2020

    • Author(s)
      松野寿生, 松本 諒, 戸谷匡康, 田中敬二
    • Organizer
      2020年繊維学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] デオキシリボ核酸鎖の界面吸着過程に及ぼすグルーブバインダーの効果2020

    • Author(s)
      柿内彩花, 盛満裕真, 松野寿生, 田中敬二
    • Organizer
      第58回日本接着学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 光架橋性官能基を導入した生体適合性接着剤の分子設計と機能2020

    • Author(s)
      戸谷匡康, 片山淳子, 小澤雅昭, 水流添暢智, 松野寿生, 田中敬二
    • Organizer
      第58回日本接着学会年次大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Si微粒子配列によるポリ(メタクリル酸2-ヒドロキシエチル)膜の凝集状態制御と細胞接着特性2020

    • Author(s)
      川畑建人, 戸谷匡康, 松野寿生, 田中敬二
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Annual Research Report
  • [Presentation] デオキシリボ核酸鎖の吸着層形成過程に及ぼすグルーブバインダーの効果2020

    • Author(s)
      柿内彩花, 盛満裕真, 松野寿生, 田中敬二
    • Organizer
      第10回CSJ化学フェスタ
    • Related Report
      2020 Annual Research Report
  • [Presentation] 水界面におけるポリオキサゾリン薄膜の凝集状態とバイオイナート特性2020

    • Author(s)
      松野寿生, Jinhyeok Hong, 戸谷匡康, 川口大輔, 山田悟史, 田中敬二
    • Organizer
      第69回高分子討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ポリメタクリル酸メチルナノファイバーマットにおける分子鎖凝集状態と熱運動性2020

    • Author(s)
      松野寿生, 松本 諒, 戸谷匡康, 田中敬二
    • Organizer
      2020年度高分子基礎物性研究会・高分子計算機科学研究会・高分子ナノテクノロジー研究会 合同討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 水界面におけるポリオキサゾリン薄膜の分子鎖凝集状態と生体不活性2020

    • Author(s)
      松野寿生, Jinhyeok Hong, 戸谷匡康, 川口大輔, 山田悟史, 田中敬二
    • Organizer
      2020年繊維学会秋季研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mechanical properties of deoxyribonucleic acid-based structural materials2020

    • Author(s)
      Hisao MATSUNO
    • Organizer
      Seoul National University -Kyushu University Joint Symposium on Materials Chemistry and Engineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 溶媒下における高分子/固体界面の形成機構2019

    • Author(s)
      松野 寿生, 盛満 裕真, 田中 敬二
    • Organizer
      2019年度高分子基礎物性研究会・高分子計算機科学研究会 合同討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Control of Surface Function of Hydrogel Thin Films Based on Si-nanoparticle Patterning2019

    • Author(s)
      Hisao MATSUNO, Yuki OGUSA, Kento KAWABATA, Masayasu TOTANI, Keiji TANAKA
    • Organizer
      68th Symposium on Macromolecules
    • Related Report
      2019 Annual Research Report
  • [Presentation] シリカ微粒子パターニングに基づくハイドロゲル薄膜の機能制御2018

    • Author(s)
      小草優希
    • Organizer
      繊維学会秋季研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 感温性ポリ(N-イソプロピルアクリルアミド)誘導体薄膜の膨潤挙動2018

    • Author(s)
      川崎浩輝
    • Organizer
      レオロジー討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 非溶媒を用いる高分子最界面の 凝集状態制御と機能化2018

    • Author(s)
      松野寿生
    • Organizer
      繊維学会秋季研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 生体成分の付着制御に寄与する高分子/水界面の凝集状態と熱運動特性2018

    • Author(s)
      松野寿生
    • Organizer
      高分子懇話会(岡山地区)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] 生体適合性接着剤2019

    • Inventor(s)
      戸谷匡康, 田中敬二, 松野寿生, 小澤雅昭, 片山 淳子
    • Industrial Property Rights Holder
      戸谷匡康, 田中敬二, 松野寿生, 小澤雅昭, 片山 淳子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-194425
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] METHOD OF PRODUCING POLYMER-IMPREGNATED BASE RESIN2018

    • Inventor(s)
      皆川康久, 田中敬二, 松野寿生, 平田豊章
    • Industrial Property Rights Holder
      皆川康久, 田中敬二, 松野寿生, 平田豊章
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2021
    • Related Report
      2020 Annual Research Report
    • Overseas

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Published: 2018-04-23   Modified: 2022-01-27  

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