| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
We clarified the structure-activity relationship of photoresponsive high-energy compounds that drive motor proteins, and discovered compounds that distinguish and drive kinesin and myosin. We have synthesized a photoresponsive inhibitor to a motor protein that arranges chromosomes in the process of the cell cycle, and succeeded in photoswitching the arrangement of chromosomes in the cell. We synthesized a photoresponsive inhibitor that acts on dynein and succeeded in photocontrolling the movement of Chlamydomonas using flagella. Furthermore, we succeeded in replacing the retinal of the proton pump with an azobenzene derivative, and confirmed the photocycle and photoinduced proton transfer. We also succeeded in creating a completely artificial molecular system that converts light energy into continuous work in contrast to proteins.
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