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Development of AIE dye for bioimaging and organic materials

Research Project

Project/Area Number 18H02045
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 35030:Organic functional materials-related
Research InstitutionTokyo Institute of Technology

Principal Investigator

Konishi Gen-ichi  東京工業大学, 物質理工学院, 准教授 (20324246)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords凝集誘起発光 / 蛍光 / 光物理過程 / 消光 / 無輻射失活 / スチルベン / 発光材料 / センサー / 蛍光色素 / アントラセン / 光機能材料 / 円錐交差
Outline of Final Research Achievements

Aggregation-induced emission (AIE) dyes, which quench fluorescence in solution and emit strongly in the solid state, have been used in a variety of applications for biomolecular imaging and solid-state luminescent materials. We focused on stilbenes, which are known to undergo large structural changes around their double bonds after irradiation. We designed an aggregation-induced luminescent dye by means of "bridged stilbene" with a alkylene chain around the double bond. We developed the bridged stilbenes BPST[7] and DPB[7], which demonstrate excellent AIE behavior.

Academic Significance and Societal Importance of the Research Achievements

液中で消光し、固体状態で強く発光する凝集誘起発光(AIE)色素は、生体分子イメージングや固体発光材料への多彩な応用が進められている。しかし、その分子設計法は未開拓な部分が多く、実在系で計算から合成・物性検討まで行った例はほとんど知られていなかった。本研究により、円錐交差に着目し、溶液中で無輻射失活をデザインできれば、合理的にAIE色素が設計できることがわかった。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (15 results)

All 2021 2020 2019 2018 Other

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (3 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Principles of Aggregation-Induced Emission: Design of Deactivation Pathways for Advanced AIEgens and Applications2020

    • Author(s)
      S. Suzuk, S. Sasaki, A. S. Sairi, R. Iwai, B. Z. Tang, G. Konishi*
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 59 Issue: 25 Pages: 9856-9867

    • DOI

      10.1002/anie.202000940

    • NAID

      120006844912

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bridged Stilbenes: AIEgens Designed via a Simple Strategy to Control the Non-radiative Decay Pathway2020

    • Author(s)
      Iwai Riki、Suzuki Satoshi、Sasaki Shunsuke、Sairi Amir Sharidan、Igawa Kazunobu、Suenobu Tomoyoshi、Morokuma Keiji、Konishi Gen-ichi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: Early View Issue: 26 Pages: 10566-10573

    • DOI

      10.1002/anie.202000943

    • NAID

      120006876577

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of fluorescent polycarbonates with highly twisted N,N-bis(dialkylamino)anthracene AIE luminogens in the main chain2019

    • Author(s)
      Sairi Amir Sharidan、Kuwahara Kohei、Sasaki Shunsuke、Suzuki Satoshi、Igawa Kazunobu、Tokita Masatoshi、Ando Shinji、Morokuma Keiji、Suenobu Tomoyoshi、Konishi Gen-ichi
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 38 Pages: 21733-21740

    • DOI

      10.1039/c9ra03701b

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis and Luminescence Properties of Diamine Monomers and Polyamides with Highly Twisted N,N-Bis(dialkylamino)arene AIE Luminogens2019

    • Author(s)
      Sharidan Sairi Amir、Konishi Gen-ichi
    • Journal Title

      Asian Journal of Organic Chemistry

      Volume: 8 Issue: 3 Pages: 404-410

    • DOI

      10.1002/ajoc.201900056

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of High-Birefringence Liquid Crystals for Future Optical Materials2018

    • Author(s)
      Arakawa Yuki、Konishi Gen-ichi
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 76 Issue: 10 Pages: 1076-1085

    • DOI

      10.5059/yukigoseikyokaishi.76.1076

    • NAID

      130007496415

    • ISSN
      0037-9980, 1883-6526
    • Year and Date
      2018-10-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New fabrication approach to develop a high birefringence photo-crosslinked film based on a sulfur-containing liquid crystalline molecule with large temperature dependence of birefringence2018

    • Author(s)
      Arakawa Yuki、Kuwahara Hiroki、Tokita Masatoshi、Konishi Gen-ichi、Tsuji Hideto
    • Journal Title

      Molecular Crystals and Liquid Crystals

      Volume: 662 Issue: 1 Pages: 197-207

    • DOI

      10.1080/15421406.2018.1467619

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] トリハロメタンを選択的に検出する光分解性ゲルの開発2018

    • Author(s)
      小西玄一
    • Journal Title

      光学

      Volume: xxx

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 橋かけ1,4ジスチリルベンゼンの立体障害導入による凝集誘起発光特性の発現2021

    • Author(s)
      岩井梨輝、小西玄一
    • Organizer
      2020年光化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] AIE色素による高分子ブレンドのガラス転移点の解析2021

    • Author(s)
      田中拓哉、小西玄一
    • Organizer
      2020年光化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] AIE色素を主鎖にもつ白色発光高分子の合成2021

    • Author(s)
      下村祥道
    • Organizer
      2020年光化学討論会
    • Related Report
      2020 Annual Research Report
  • [Remarks] 凝集誘起発光とは何か?その本質が明らかに

    • URL

      https://www.titech.ac.jp/news/2020/047135.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 凝集誘起発光の本質を解明 -理論化学で発光現象を映画のように視覚的に再現-

    • URL

      https://www.kyoto-u.ac.jp/ja/research-news/2020-05-22

    • Related Report
      2020 Annual Research Report
  • [Remarks] 理論計算による新設計法で凝集誘起発光色素の開発に成功

    • URL

      https://www.titech.ac.jp/news/2020/046525.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 理論計算による新設計法で凝集誘起発光色素の開発に成功

    • URL

      https://www.kyoto-u.ac.jp/ja/research-news/2020-04-08-0

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 低い相転移温度を示す環状構造を含む液晶分子2020

    • Inventor(s)
      小西玄一、岩井輝梨
    • Industrial Property Rights Holder
      小西玄一、岩井輝梨
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-141451
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2023-12-25  

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