Creation of new drug targets based on marine natural products
| Project/Area Number |
18H02096
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
君嶋 敦 大阪大学, 薬学研究科, 特任助教(常勤) (20812134)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 海洋天然物 / 標的分子 / 生物活性 / 創薬標的 |
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| Outline of Final Research Achievements |
In recent years, novel drug targets for cancer and infectious diseases (tuberculosis and amoebiasis) have been difficult to discover. In this study, we conducted an exploratory study of bioactive marine natural products effective for cancer and infectious diseases using established screening systems focusing on unique phenotypic changes of cells and pathogenic microbes in tumor and infected region. As a result, 11 bioactive marine natural products including a new compound were discovered. In addition, target molecule analysis was performed for a total of seven compounds, and target molecules were successfully identified for four of them.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで新規創薬標的は、細胞、動物、病原体等を用いた生物学または分子生物学的な手法による病態解析から見出される場合がほとんどであった。本研究は、創薬標的の枯渇が問題となっている「がん」や「感染症」に対して、それらに有効な海洋天然物（活性天然物）の探索と取得を行い、その結合タンパク質の解析を通して新たな創薬標的の開拓を目指している。本手法はこれまでとは異なるアプローチによる研究であり、見出された結合タンパク質はこれまでとは異なる新規創薬標的となる可能性が高い。また、見出した活性天然物は、医薬シーズとしての応用展開が可能であることから創薬化学領域への波及効果も期待できる。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Direct visualization of an antidepressant analog using surface-enhanced Raman scattering in the brain2020
Author(s)
Masato Tanuma, Atsushi Kasai, Kazuki Bando, Naoyuki Kotoku, Kazuo Harada, Masafumi Minoshima, Kosuke Higashino, Atsushi Kimishima, Masayoshi Arai, Yukio Ago, Kaoru Seiriki, Kazuya Kikuchi, Satoshi Kawata, Katsumasa Fujita, Hitoshi Hashimoto
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Journal Title
JCI Insight
Volume: 5
Issue: 6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of biosynthetic genes for the β-carboline alkaloid kitasetaline and production of the fluorinated derivatives by heterologous expression2019
Author(s)
Ueda, S., Ikeda, H., Namba, T., Ikejiri, Y., Nishimoto, Y., Arai, M., Nihira, T., Kitani, S.,
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Journal Title
J. Ind. Microbiol. Biotechnol.
Volume: -
Issue: 5
Pages: 739-750
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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