| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
By further expanding the chemistry of azide and its reaction partner, azidophile, we have worked on the development of molecular conjugation methods that are useful for promoting life science research and preparing new biopharmaceuticals. In particular, we aimed to develop practical methods such as a method that can leave more reactive moieties untouched and also a method for synthesizing molecules that have multiple functional moieties. As a result, we have succeeded in developing various sequential molecular conjugation methods based on several new azide type-selective reactions and reactivity control methods for cyclic alkynes.
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