| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Outline of Final Research Achievements |
Protein-protein interactions (PPIs) implicate in various diseases and intense efforts have focused on developing PPI-directed pharmaceuticals. However, structure-based drug design using drug-like small molecules still remains a difficult challenge due to the fact that the PPI interfaces that are often flat and flexible as seen in intrinsically disordered proteins (IDPs). Thus, a new methodology for designing and constructing synthetic agents that are capable of controlling intracellular PPIs that are reversible and transient. In this study, we elucidated three approaches based on synthetic molecules for controlling PPIs of intrinsically disordered proteins.
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