| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Crh in Gram-positive bacteria is supposed to be involved in glucose catabolite repression. It was found that the iol gene cluster for inositol metabolism in Geobacillus kaustophilus (GK) was not repressed by glucose but by excessive phosphorylation of Crh. In addition, phosphorylated Crh forms a complex with CcpA to exert the repression. The iol genes were repressed by xylose and ribose, indicating that Crh is required for the repression by these 5-carbon sugars. In addition, the expression of hpr was markedly lower in GK, whereas that of crh was higher, suggesting that in GK Crh might be responsible for the catabolite repression by 5-carbon sugars.
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