Importance of lanthanides in microorganisms
| Project/Area Number |
18H02129
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 38020:Applied microbiology-related
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| Research Institution | Okayama University |
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Principal Investigator |
Tani Akio 岡山大学, 資源植物科学研究所, 准教授 (00335621)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | Methylotroph / Lanthanides / Methanol dehydrogenase / Methylotrophs / Methylobacterium / lanthanide / methylotrophs / lanthanides / xoxF |
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| Outline of Final Research Achievements |
Methylobacterium species are phytosymbionts utilizing methanol emitted from plants. They utilize two different methanol dehydrogenases (MDHs) that require calcium and lanthanides. We examined the regulation mechanism of Ln-dependent gene expression, and found factors involved in the regulation. On the other hand, Ln-dependent MDH gene is encoded in many bacterial genomes. We found and characterized new Ln-dependent methylotrophs.
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| Academic Significance and Societal Importance of the Research Achievements |
ランタノイドは天然には広く存在するが実験室環境には存在しないため、それに依存する微生物の生育、代謝系の制御の理解は自然界での微生物の振る舞いを理解する上で重要である。本研究ではランタノイドを生育に要求する微生物を新規に見いだし、その依存性をゲノムや酵素遺伝子の観点から証明した。またMethylobacterium属細菌についてランタノイドによる代謝酵素遺伝子制御のメカニズムの一端を明らかに出来た。
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Regulation of lanthanide-dependent methanol oxidation pathway in the legume symbiotic nitrogen-fixing bacterium Bradyrhizobium sp. strain Ce-32020
Author(s)
Viagian Pastawan, Soya Suganuma, Kosuke Mizuno, Lun Wang, Akio Tani, Ryoji Mitsui, Kohei Nakamura, Masaya Shimada, Takashi Hayakawa, Nanung Agus Fitriyanto, and Tomoyuki Nakagawa
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Journal Title
Journal of Bioscience and Bioengineering
Volume: 130
Issue: 6
Pages: 582-587
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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