| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
The gate effect of the biological clock supports oscillations of clock genes that are robust to environmental fluctuations by restricting the input of environmental signals to specific time periods. DNA methylation and histone acetylation in the regulatory regions of gene expression are known to cause conformational changes in chromatin that define the potential for transcriptional activity. In this study, we focus on the PRR family and its target gene CCA1/LHY, which form a negative feedback loop circuit in the central oscillator of Arabidopsis thaliana, to clarify how the PRR family plays a role in the regulation of chromatin structure in the central oscillator.
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