| Project/Area Number |
18H02157
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
津田 孝範 中部大学, 応用生物学部, 教授 (90281568)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 糖尿病前症 / 糖尿病予防 / ポリフェノール / エネルギー代謝 / インクレチン / AGE / 終末糖化産物 / 糖尿病 / 最終糖化産物 / 機能性食品 / 食品成分 |
|---|
| Outline of Final Research Achievements |
In this study, we aimed to investigate bioactive food compounds showing anti-pre-diabetic effect in vivo and to elucidate the underlying mechanism. Using spontaneously hyperglycemic rats (SDT rats), which possess normal fasting blood glucose level even in pre-diabetic stages, we demonstrated the novel anti-pre-diabetic findings that 6-O-caffeoylquinic acid, Del-3-O-rutinoside, and theaflavins can ameliorate glucose tolerance by promoting incretin secretion and energy consumption via prohormone convertase1/3 and AMPK activation at the small intestine.
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| Academic Significance and Societal Importance of the Research Achievements |
空腹時血糖値の上昇が糖尿病発症の診断尺度であるが、空腹時血糖値は正常であっても食後の過血糖値の改善が不全である隠れ糖尿病をあぶり出し、改善する食品成分については研究報告例がない。本研究では、この改善作用を発揮する食品成分を明らかにした点で大いに評価され、糖尿病を未病段階で改善できる新たな機能性食品の開発に資する成果を得ているといえる。
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