| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
The gustatory system plays a critical role in sensing appetitive and aversive taste stimuli for evaluating food quality. While the peripheral gustatory system is well studied these days, the gustatory system in the brain is still unclear. Although taste preference is known to change depending on internal states such as hunger, a mechanistic insight remains unclear. In this study, we investigated neuronal mechanism that transduce or modulate the gustatory sensation using transgenic mice and recombinant adeno-associated virus based functional assays. We first succeeded in the identification of neuronal cells that specifically transduce sweet taste in the brain stem. We next found that hypothalamic neuronal network that regulate hunger-induced taste modification. These results will provide us the neural basis for pleasant taste.
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