| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Outline of Final Research Achievements |
The histone variant H2A.Z functions in the regulation of gene expression through its deposition and eviction. However, the mechanisms of the molecular function of H2A.Z was largely unknown. In this study, we showed the relationship between H2A.Z function and nuclear actin family proteins by using knockout cells for H2A.Z and actin family proteins. In addition, by using bicyclic peptides for Arp6 and Arp8, we identified molecular mechanisms regulating deposition and eviction of H2A.Z.
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