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Exploring the effects of microplastics drifting in the ocean on living organisms through multi-omics analyses of mussels

Research Project

Project/Area Number 18H02261
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 40030:Aquatic bioproduction science-related
Research InstitutionThe University of Tokyo

Principal Investigator

Inoue Koji  東京大学, 大気海洋研究所, 教授 (60323630)

Co-Investigator(Kenkyū-buntansha) 小島 茂明  東京大学, 大学院新領域創成科学研究科, 教授 (20242175)
水川 薫子  東京農工大学, (連合)農学研究科(研究院), 助教 (50636868)
新里 宙也  東京大学, 大気海洋研究所, 准教授 (70524726)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywordsムラサキイガイ / 海洋汚染 / トランスクリプトーム / メタボローム / マイクロプラスチック / イガイ類 / 遺伝子
Outline of Final Research Achievements

Although marine pollution by microplastics (MPs) is of world-wide concern, its actual effects on marine organisms are not fully understood. In this study, we established an experimental system to make marine mussels (Mytilus galloprovincialis) ingest MPs, and found that retention time in the digestive tract is size-dependent.
Subsequently, we conducted transcriptome, metabolome, and heart rate analyses on the mantle, digestive tracts, and gonads after exposure of the mussels to model MPs and those absorbed PCBs (PCB-MPs). The results suggested that exposure to MPs and PCB-MPs induce unknown physiological reactions as the many genes that responded to the exposure are unknown genes.

Academic Significance and Societal Importance of the Research Achievements

本研究ではMP汚染の影響を調べる実験系を、都市近郊に分布し、大量の浮遊粒子を濾過食によって取り込む性質がある一方、食用種でもあるムラサキイガイ(ムール貝)を用いて確立した。この成果を参考にした多くの論文が発表されており、世界のMP影響研究の進展に貢献できた。
同種が粒子を取り込む動画も作成し、その発表論文も多くのアクセスを得ている。
さらに、MPやPCB-MPに対する生理応答に多くの未知遺伝子が関与することがわかった。これらを正確に理解するには、貝類の遺伝子や代謝に関する情報を今後より充実させる必要がある。比較解析のために解読した近縁のミドリイガイのゲノム配列も世界中で利用されている。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (5 results)

All 2021 2019 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Genomics and transcriptomics of the green mussel explain the durability of its byssus2021

    • Author(s)
      Koji Inoue, Yuki Yoshioka, Hiroyuki Tanaka, Azusa Kinjo, Mieko Sassa, Ikuo Ueda, Chuya Shinzato, Atsushi Toyoda, Takehiko Itoh
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 992-992

    • DOI

      10.1038/s41598-021-84948-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mussel biology: from the byssus to ecology and physiology, including microplastic ingestion and deep-sea adaptations2021

    • Author(s)
      Koji Inoue, Yuri Onitsuka, Tomoko Koito
    • Journal Title

      Fisheries Science

      Volume: 87 Issue: 6 Pages: 761-771

    • DOI

      10.1007/s12562-021-01550-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Size-dependent elimination of ingested microplastics in the Mediterranean mussel Mytilus galloprovincialis2019

    • Author(s)
      Azusa Kinjo, Kaoruko Mizukawa, Hideshige Takada, Koji Inoue
    • Journal Title

      Marine Pollution Bulletin

      Volume: 149 Pages: 110512-110512

    • DOI

      10.1016/j.marpolbul.2019.110512

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミドリイガイ全ゲノム配列の解明と足糸関連遺伝子の探索2021

    • Author(s)
      井上広滋・善岡祐輝・田中裕之・ 金城梓・佐々三依子・植田育男・ 新里宙也・豊田敦・伊藤武彦
    • Organizer
      令和3年度日本水産学会春季大会
    • Related Report
      2020 Annual Research Report
  • [Remarks] ミドリイガイのゲノム解析からわかった足糸の耐久性の秘密

    • URL

      https://www.aori.u-tokyo.ac.jp/research/news/2021/20210316.html

    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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