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Elucidation study of antifouling mechanism with natural product derivatives for development of green antifoulant

Research Project

Project/Area Number 18H02271
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 40040:Aquatic life science-related
Research InstitutionHokkaido University

Principal Investigator

Umezawa Taiki  北海道大学, 地球環境科学研究院, 准教授 (20503618)

Co-Investigator(Kenkyū-buntansha) 野方 靖行  一般財団法人電力中央研究所, 環境科学研究所, 上席研究員 (10371535)
沖野 龍文  北海道大学, 地球環境科学研究院, 教授 (30280910)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords付着生物 / 天然有機化合物 / 付着阻害 / メカニズム解明 / プローブ合成 / 構造活性相関 / 全合成
Outline of Final Research Achievements

Utilization of marine is essential for human activities. The utilizations through ship or cooling pipe for power plant result settlement by organisms to induce waste costs through excess use of oil or clogging pipes. To prevent the settlement, although compounds including heavy metals are used, they are pointed to be toxic against marine organism and environmental. In this study, it was envisioned that natural marine products as defense system of marine livings against the fouling organisms can be used for a green and potent antifouling material through revealing the mechanism of the antifouling system by these compounds.

Academic Significance and Societal Importance of the Research Achievements

付着生物による経済損失(清掃費用、メンテナンス作業のため装置停止など)は、日本だけでなく世界的な課題である一方、既存の付着阻害剤は海洋環境の持続可能性を脅かすと指摘されている。本研究では、強力な付着阻害活性とごく低毒性を併せ持つ化合物を対象としている。付着生物に対する分子生物学的研究は発展途上であり、本分野への貢献につながる。また、本研究によって得られる成果は、安価な低毒性付着阻害化合物の開発へとつなげていけるので、海洋環境の保全への展開が期待できる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (23 results)

All 2022 2021 2020 2019 2018

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results)

  • [Journal Article] Effective Synthesis and Antifouling Activity of Dolastatin 16 Derivatives2022

    • Author(s)
      Casalme Loida O.、Katayama Keisuke、Hayakawa Yoshiki、Nakamura Kensuke、Yamauchi Arisa、Nogata Yasuyuki、Yoshimura Erina、Matsuda Fuyuhiko、Umezawa Taiki
    • Journal Title

      Marine Drugs

      Volume: 20 Issue: 2 Pages: 124-124

    • DOI

      10.3390/md20020124

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides through a simple work-up procedure2021

    • Author(s)
      Prakoso Nurcahyo Iman、Matsuda Fuyuhiko、Umezawa Taiki
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 19 Issue: 36 Pages: 7822-7826

    • DOI

      10.1039/d1ob01379c

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Assignment of Absolute Configuration of Bromoallenes by Vacuum-Ultraviolet Circular Dichroism (VUVCD)2021

    • Author(s)
      T. Umezawa, N. Mizutani, K. Matsuo, Y. Tokunaga, F. Matsuda, T. Nehira
    • Journal Title

      Molecules

      Volume: 26 Issue: 5 Pages: 1296-1296

    • DOI

      10.3390/molecules26051296

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neighboring Effect of Intramolecular Chlorine Atoms on Epoxide Opening Reaction by Chloride Anions2019

    • Author(s)
      Taiki Umezawa, Masayuki Shibata, Ryutaro Tamagawa, Fuyuhiko Matsuda
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 19 Pages: 7731-7735

    • DOI

      10.1021/acs.orglett.9b02624

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Structure?Activity Relationship of Omaezallene Derivatives2019

    • Author(s)
      Umezawa Taiki、Prakoso Nurcahyo Iman、Kannaka Miho、Nogata Yasuyuki、Yoshimura Erina、Okino Tatsufumi、Matsuda Fuyuhiko
    • Journal Title

      Chemistry & Biodiversity

      Volume: 16 Issue: 1 Pages: 1800451-1800451

    • DOI

      10.1002/cbdv.201800451

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A study on synthesis of antifouling natural products and their derivatives2018

    • Author(s)
      Umezawa Taiki、Matsuda Fuyuhiko
    • Journal Title

      Sessile Organisms

      Volume: 35 Issue: 2 Pages: 35-44

    • DOI

      10.4282/sosj.35.35

    • NAID

      130007495130

    • ISSN
      1342-4181, 1883-4701
    • Year and Date
      2018-10-05
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Total Synthesis of Omaezallene toward Structure Determination2018

    • Author(s)
      Umezawa Taiki
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 76 Issue: 5 Pages: 426-429

    • DOI

      10.5059/yukigoseikyokaishi.76.426

    • NAID

      130006733940

    • ISSN
      0037-9980, 1883-6526
    • Year and Date
      2018-05-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synthetic Study on Mollenyne A2022

    • Author(s)
      Nurcahyo Iman Prakoso, Shi Quan, Taiki Umezawa
    • Organizer
      日本化学会 第102春季年会 (2022)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Mitchellene Fの合成研究2021

    • Author(s)
      小林拓夢、梅澤大樹
    • Organizer
      日本化学会北海道支部2021年夏季研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Synthetic study on Mollenyne A2021

    • Author(s)
      石泉、梅澤大樹
    • Organizer
      日本化学会北海道支部2021年夏季研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Study of nucleophilic addition reaction toα, β-chlorinated Weinreb amide2021

    • Author(s)
      NURCAHYO IMAN PRAKOSO、梅澤大樹、松田冬彦
    • Organizer
      日本化学会北海道支部2021年夏季研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Mitchellene の合成研究2021

    • Author(s)
      小林拓夢、梅澤大樹
    • Organizer
      第33回万有札幌シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] Study of nucleophilic addition reaction toα, β-chlorinated Weinreb amide2021

    • Author(s)
      NURCAHYO IMAN PRAKOSO、梅澤大樹、松田冬彦
    • Organizer
      21st Tetrahedron Symposium 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 付着生物が忌避する有機化合物の合成研究2021

    • Author(s)
      梅澤大樹
    • Organizer
      日本鉄鋼協会 評価・分析・解析部会「化学的または生物学的処理によるスラグの機能変化とその評価・分析フォーラム」講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ドラスタチン16誘導体の合成研究2020

    • Author(s)
      片山佳祐・松田冬彦・梅澤大樹
    • Organizer
      第32回万有札幌シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] オマエザレン誘導体の合成研究2019

    • Author(s)
      岩谷怜生・梅澤大樹・松田冬彦
    • Organizer
      日本化学会北海道支部2019年夏季研究発表会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Total Synthesis and Structure-Activity Relationship of Omaezallene2019

    • Author(s)
      Taiki Umezawa
    • Organizer
      26th International symposium: Synthesis in organic chemistry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 海洋構造物の付着生物除去用化学物質の開発2019

    • Author(s)
      梅澤大樹
    • Organizer
      笹川科学研究助成研究成果発表会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] オマエザレン誘導体の合成研究2018

    • Author(s)
      水谷央・梅澤大樹・松田冬彦
    • Organizer
      第30回記念 万有札幌シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dolastatin 16誘導体の合成研究2018

    • Author(s)
      早川嘉樹・山内有紗・梅澤大樹・松田冬彦
    • Organizer
      北海道支部2018年夏季研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] オマエザレン鏡像体の合成研究2018

    • Author(s)
      水谷央・梅澤大樹・松田冬彦
    • Organizer
      北海道支部2018年夏季研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dolastatin 16誘導体の合成研究2018

    • Author(s)
      早川嘉樹・中村謙介・Loida O. Casalme・ 梅澤大樹・松田冬彦
    • Organizer
      第60回 天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Total Synthesis of Antifouling Natural Products toward Development of Molecular Probe2018

    • Author(s)
      梅澤大樹
    • Organizer
      International Congress on Pure & Applied Chemistry Langkawi (ICPAC Langkawi )
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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