| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
|
|---|
| Outline of Final Research Achievements |
To understand the pathogenesis of rabies, it is necessary to uncover the replication mechanism of rabies virus and the host immune response against the infection. In this study, we investigated the role of host factors involved in the intracellular replication of rabies virus and host innate immune response to the infection. We revealed that astrocytes infected with rabies virus HEP, an attenuated strain, produce interferon and trigger subsequent antiviral responses for virus elimination and recovery from the infection. We also demonstrated that the host ESCRT mechanism facilitates the budding of rabies virus virion from the infected cells and is involved in the ballet-shaped virion morphology.
|
