| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Although Fanconi syndrome is a multifactorial disease, its clinical features are based on reduced reabsorption of water, solutes, and nutrients in the kidneys, especially in the proximal tubules. So far, the mechanism by which the common symptom of reabsorption deficiency occurs largely unknown. From this study, we have identified a new mechanism of renal endoplasmic reticulum stress for this deficiency. Also, we have shown that at least two gene expressions are directly linked to the symptom. These results provide important information for human and veterinary clinical fields and indicate a new regulatory system for substance metabolism in the kidney.
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