| Budget Amount *help |
¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
We have developed the novel method named ISLAP that comprehensively identifies the V. vulnificus genes required to evade neutrophils. Among 40 identified genes, VV1_0055 and VV1_0056 were involved in a protein transport system from inner membrane to outer membrane in periplasm. 0055 binds Enoyl-[acyl-carrier-protein] reductase [NADH] 2, which is the enzyme for Acyl ACP synthesis. Interestingly, 0058, 0059, 0060 and 0061 were found on the same pathway for Acyl ACP. Thus, the acylated proteins modified by 0055 and 0056 are involved in ability of evading neutrophils.
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