Functional exploration and translational research of Neuromedin U / S and these novel related peptides
| Project/Area Number |
18H02354
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 42030:Animal life science-related
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| Research Institution | University of Miyazaki |
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Principal Investigator |
MURAKAMI NOBORU 宮崎大学, フロンティア科学総合研究センター, 特別教授 (80150192)
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| Co-Investigator(Kenkyū-buntansha) |
井上 賀之 宮崎大学, 農学部, 助教 (60807436)
中原 桂子 宮崎大学, 農学部, 教授 (90315359)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | ニューロメジンU / ニューロメジンS / 新規ペプチド / 自律神経 / 下垂体ホルモン / ニューロメジン関連ペプチド / 摂食 / エネルギー代謝 / NURP / NSRP / ｃFos / 蛍光免疫染色 / neuromedin U / neuromedin S / 中枢作用 / ＮＵＲＰ / ＮＳＲＰ / ＮＭＵ / ＮＭＳ |
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| Outline of Final Research Achievements |
There is another functional peptide for each of the precursors of Neuromedin U (NMU) and Neuromedin S (NMS). They were named NURP (NMU precursor-related peptide) and NSRP (NMS precursor-related peptide). Physiological functions of these peptides (effects on feeding, body temperature, energy metabolism, heart rate, or pituitary hormones secretion), and action site of these peptides was examined in a rat with the experiment of icv injection. It was found that NURP and NSRP act on the other sites with NMU or NMS, and each has a specific physiological action. From the above results, it was speculated that these novel peptides were excised at the site of the brain in a timely manner and acted on specific receptors.
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| Academic Significance and Societal Importance of the Research Achievements |
生体内には未だ同定されていないペプチドが数多く存在する。新規ペプチドの発見とその生理作用の解明は、生体内の様々な生理機能や機序に新たな解釈を与え、新薬の開発につながる可能性が極めて大きい。これまでに、我々はグレリン、ニューロメジンU (以下NMUと略)やニューロメジンS（以下NMSと略) などの新規ペプチドの同定や作用を解明し,摂食機構の新たな仕組み、ホルモンの自律神経様作用の発見、ホルモンと神経のクロストークなど、これまでの常識や解釈を覆す事実を提示してきた。本研究は、新規ペプチドNURPとNSRPの機能をNMUやNMSと比較しながら、網羅的に解明し、創薬への橋渡しをすることにある。
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Immunostimulatory effect of kumquat (Fortunella crassifolia) and its constituents, β-cryptoxanthin and R-limonene2019
Author(s)
Rina Terao, Akira Murata, Kazuhiro Sugamoto, Tomoko Watanabe, Kiyoko Nagahama, Keiko Nakahara, Tomomi Kondo, Noboru Murakami, Keiichi Fukui, Hidemi Hattori, Nozomu Eto
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Journal Title
Food & Function
Volume: 10
Issue: 1
Pages: 38-48
DOI
Related Report
Peer Reviewed
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