| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
|---|
| Outline of Final Research Achievements |
The purpose of this study was to elucidate the mechanism by which "social adaptability" in mammalian animals develops by maternal factors. First, we found that the infant-specific oxytocin nervous system is one of the neural systems responsible for the development of social adaptability. We also searched for a new responsible nervous system and found that there are memory cells in the paraventricular nucleus of thalamus and hippocampal dentate gyrus that are activated both by maternal stimuli in infancy and during maternal behavior in adulthood. We focused on maternal licking/grooming as one of the maternal factors, and found that pain sensitivity increased when caress-sensitive nerves in the pups were specifically suppressed in the early stages of life. From experiments using artificially reared mice, we also found that Lactobacillus in mother's milk is a maternal factor that promotes the development of sociability and cognitive ability in the pups.
|
