| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
To analyze epigenomic information of the cell, it has been a normal practice to acquire an average information across millions of cell population that are regarded as homogeneous. However, recent technical progress has enabled to detect epigenomic information from single cells. These single-cell approaches have revealed heterogeneity within a "homogeneous" cell population, for example minor cell groups with distinct epigenomic characteristics and dynamic reorganization of the epigenomic information. To make the most of such unprecedented findings, it is ideal to acquire multiple epigenomic information from the same single cells and correlate them with each other within each single cell, which is still technically challenging. In this study, we have developed a new method to get information on three-dimensional chromatin structure and cellular phenotype simultaneously from the same single cells.
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