| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Outline of Final Research Achievements |
We developed a technology to control protein aggregation by adding a short solubility-controlling peptide tag (SCP tag) to the termini of two model proteins, BPTI and ED3, using recombinant DNA technology. We found that an SCP tag consisting of 5 Ile not only oligomerized the proteins into soluble aggregates but also increased immunogenicity by more than 200-fold compared to that of the wild type.
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