| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
Primary cilia are organelles that function as a cellular antennas. Defects in primary cilia cause a hereditary disorder called ciliopathies with a variety of severe symptoms. The intraflagellar transport (IFT) machinery is a protein complex consisting of more than 40 different proteins. Ciliary protein transport by the IFT machinery plays an essential role in the function of cilia. In this study, we elucidated some of the functions of IFT machinery using various methods, including visible immunoprecipitation (VIP) assay, CRISPR/Cas9 genome editing, and super-resolution imaging by expansion microscopy.
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