| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
The role of DOCK1 and its related proteins in tumor immune evasion was investigated. DOCK1-Rac signal was associated with the expression of some of the interferon-responsive genes as well as STAT3 phosphorylation. Genetic ablation of DOCK1 in cancer cells resulted in marked infiltration of immune cells into tumor in vivo. A lipid metabolite that functions as an endogenous inhibitor of DOCK2 and regulates immune cell motility was identified. Thus, the study elucidates the critical roles of DOCK1 and related proteins in tumor-immune interactions, which could be exploited for the future development of novel anticancer therapeutics.
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